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Genetic variants associated with longevity in long-living Indians.
NPJ Aging
November 2024
Mapmygenome India Limited, Hyderabad, India.
Article Synopsis
- Genetic factors significantly influence how long individuals live, and this study focuses on identifying these genetic variants in the Indian population by comparing individuals aged 85+ (long living individuals, LLIs) with younger controls aged 18-49.
- The research utilized a custom chip for genetic data, revealing 9 variants linked to longevity, with certain alleles associated with positive traits like slower heart rate and lower risks for various disorders being more common in LLIs, while other risky alleles were less frequent.
- The study also found that genes related to oxidative stress, DNA repair, and metabolism play important roles in healthy aging and longevity, confirming the genetic basis for these traits in the population.
Association between ZFHX3 and PRRX1 Polymorphisms and Atrial Fibrillation Susceptibility from Meta-Analysis.
Int J Hypertens
December 2021
Medical Laboratory, Shidong Hospital, Affiliated to University of Shanghai for Science and Technology, No. 999, Shiguang Road 200438, Yangpu District, Shanghai, China.
Background: Atrial fibrillation (AF) is a common, sustained cardiac arrhythmia. Recent studies have reported an association between ZFHX3/PRRX1 polymorphisms and AF. In this study, a meta-analysis was conducted to confirm these associations.
View Article and Find Full Text PDFPRRX1 Rs3903239 polymorphism and atrial fibrillation in a Greek population.
Hellenic J Cardiol
June 2019
Department of General Biology, Medical School, Aristotle University of Thessaloniki, Greece. Electronic address:
The rs3807989 G/A polymorphism in CAV1 is associated with the risk of atrial fibrillation in Chinese Han populations.
Pacing Clin Electrophysiol
February 2015
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: A recent meta-analysis of several genome-wide association studies identified six new susceptibility single nucleotide polymorphisms (SNPs) for atrial fibrillation (AF) in individuals of the European ancestry. We aimed to replicate the associations between these SNPs and the risk of AF in a Chinese Han population.
Methods: We genotyped six SNPs (rs3903239 in PRRX1, rs3807989 in CAV1, rs10821415 in C9orf3, rs10824026 in SYNPO2L, rs1152591 in SYNE2, and rs7164883 in HCN4) using the middle-throughput iPLEX Sequenom MassARRAY platform.
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