Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.amjmed.2017.12.030 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Giant cavernous malformation: a rare paediatric presentation.
BMJ Case Rep
March 2025
Radiology, King's College London, London, UK.
A boy in middle childhood with a history of early morning headaches presented to secondary care after being found to have bilateral papilloedema by his community optometrist. CT head showed a large right-sided heterogeneous calcific and haemorrhagic mass causing marked mass effect and midline shift. Preoperatively, the lesion was characterised on MRI as a haemorrhagic mass with a 'popcorn' appearance suggestive of a giant cavernous malformation measuring 6.
View Article and Find Full Text PDFFahr's syndrome is a rare, progressive, neuropsychiatric disorder characterized by bilateral and symmetrical calcifications over the basal ganglia and other parts of the brain, leading to a wide range of clinical manifestations ranging from neurologic symptoms of movement disorders, seizures, and cerebellar dysfunction to neuropsychiatric symptoms such as dementia, psychosis, and mood disorders. The widespread calcific deposits within the brain tissue that characterize Fahr's syndrome develop secondary to different underlying conditions such as parathyroid disorders, brain infections, and toxic exposures. Hypoparathyroidism, a rare disorder of calcium and phosphate metabolism, is the most commonly identified etiology of Fahr's syndrome.
View Article and Find Full Text PDFZika, a mosquito-borne flavivirus, has been found in 87 countries and territories. Global outbreaks peaked in 2016. Prenatal infection of Zika virus was found to be associated with microcephaly, arthrogryposis, intracranial calcifications, fetal growth restriction, and fetal demise.
View Article and Find Full Text PDFShort-term efficacy of tofacitinib, a JAK inhibitor, in IFIH1-related Aicardi-Goutières syndrome.
Eur J Med Genet
March 2025
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, 110004, China. Electronic address:
Aicardi-Goutières syndrome (AGS) is a genetically heterogeneous type-I interferonopathy presenting in infancy with intracranial calcifications, white matter lesions, and brain atrophy. AGS7, caused by gain-of-function (GOF) mutations in the IFIH1 gene, triggers excessive type-I interferon production, leading to autoimmune responses. We describe an 18-year-old female diagnosed with AGS7 due to a somatic GOF mutation in IFIH1.
View Article and Find Full Text PDFEffect of the aspect ratio and wall heterogeneities on the mechanical behaviour of the aneurysm wall: Experimental investigation on phantom arteries.
J Mech Behav Biomed Mater
June 2025
Laboratoire de Tribologie et Dynamique des Systèmes, UMR CNRS 5513, Ecole Centrale Lyon, 69130, Ecully, France; Université de Lyon, Université Claude Bernard Lyon 1, ISPB-Faculté de Pharmacie de Lyon, 69008, Lyon, France. Electronic address:
The management of unruptured intracranial aneurysms (UIA) involves assessing the risk of rupture, which requires a thorough understanding of risk factors such as the geometric characteristics of the neck (neck size) or local structural heterogeneities. This study explores the impact of neck size on the rupture risk of the aneurysmal sac and examines how local heterogeneities, such as calcifications or variations in tissue composition, influence the mechanical response of the wall of a saccular aneurysm during the insertion of an innovative arterial wall deformation device (DDP). The results reveal that high aspect ratios (AR) are associated with increased hemodynamic stress, thereby raising the risk of rupture.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!