We report a case of a 28-year-old female who presents with painless, progressively increasing left upper chest swelling of 6 months duration. Examination revealed a 20 by 10 cm firm mass arising from the clavicle. She was investigated and a diagnosis established based on the histological report. The tumour was excised with a wide margin and reconstruction done with an autogenous fibula graft. Full functional ability was restored in limb with the radiological union. After 5 years of regular follow-up, there was no evidence of recurrence and shoulder function remained excellent. The successful management of this patient shows wide local excision and reconstruction as an excellent surgical option in treating giant cell tumour of the clavicle.
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http://dx.doi.org/10.4103/npmj.npmj_133_17 | DOI Listing |
J Craniofac Surg
November 2024
Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL.
Giant cell tumors (GCTs) are benign but locally aggressive bone neoplasms that primarily affect skeletally mature individuals. They are characterized by a tendency for recurrence and being associated with significant morbidity. Traditional treatment has focused on surgical resection; however, the role of medical therapies, such as Denosumab, a bone anti-resorptive drug, which has been Food and Drug Administration (FDA)-approved for unresectable GCTs since 2013, recently has gained prominence.
View Article and Find Full Text PDFJ Am Acad Orthop Surg
November 2024
From the Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY (Albanese, Lynch, and Damron), and the Department of Orthopaedic Surgery, Virginia Commonwealth University, Richmond, VA (Eswaran).
Beyond enchondromas, the most common bone tumors of the hand, there are numerous less common benign bone tumors and mimickers with which orthopaedic and hand surgeons should be familiar. These include other benign cartilage tumors, cystic lesions, osteogenic tumors, giant cell tumor, and fibrous dysplasia. Particularly unique lesions include bizarre parosteal osteochondromatous proliferation (Nora lesion), florid reactive periostitis, turret exostosis (acquired osteochondroma), giant cell reparative granuloma (solid aneurysmal bone cyst), and epidermoid cyst.
View Article and Find Full Text PDFBMJ Case Rep
January 2025
Department of Respiratory Medicine, Alfred Health, Melbourne, Victoria, Australia
Excipient lung disease (ELD) is a rare cause of pulmonary hypertension that occurs due to the intravenous injection of crushed tablets. We present the case of a healthcare professional in her late 30s who presented with a fever in the setting of a bacteraemia. During her hospital admission, she established a pattern of transient hypoxia and hypotension, with resolution without targeted management or clear cause identified.
View Article and Find Full Text PDFProc Biol Sci
January 2025
Department of Zoology, Faculty of Science, Charles University, Prague 128 43, Czech Republic.
African mole-rats (Bathyergidae, Rodentia) are subterranean rodents that live in extensive dark underground tunnel systems and rarely emerge aboveground. They can discriminate between light and dark but show no overt visually driven behaviours except for light-avoidance responses. Their eyes and central visual system are strongly reduced but not degenerated.
View Article and Find Full Text PDFClin Exp Rheumatol
January 2025
Division of Rheumatology, Mayo Clinic, Rochester, MN, USA.
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