AI Article Synopsis
- The study focused on creating different chitosan derivatives to stabilize gold nanoparticles (AuNPs) for potential medical applications.
- Variations of the chitosan derivatives included folate and galactosyl modifications, which were synthesized and tested for effectiveness in stabilizing AuNPs.
- Results indicated that while the derivatives were non-toxic to human cells, the folate-modified AuNPs had better internalization in certain cancer cells compared to the unmodified versions.
Article Abstract
In this study, we synthesized various quaternary chitosan derivatives and used them to stabilize gold nanoparticles (AuNPs). These chitosan derivatives comprised N-(2-hydroxy)propyl-3-trimethylammonium chitosan chloride (HTCC), folate-HTCC, galactosyl-HTCC, and their fluorescein isothiocyanate-conjugated derivatives. Various positively surface-charged AuNPs were prepared under alkaline conditions using glucose as a reducing agent in the presence of the HTCC derivatives (HTCCs). The effects of the concentration of NaOH, glucose, and HTCCs on the particles size, zeta potential, and stability were studied in detail. Cell cycle assays verify that none of the HTCCs or HTCCs-AuNPs was cytotoxic to human umbilical vein endothelial cells. Flow cytometry analysis showed that the folate HTCC-AuNPs were internalized in Caco-2, HepG2, and HeLa cancer cells to a significantly greater extent than AuNPs without folate. But, galactosyl HTCC-AuNPs only showed high cell uptake by HepG2 cells.
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| http://dx.doi.org/10.1016/j.carbpol.2017.11.096 | DOI Listing |
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