Pituitary adenomas account for the top three primary intracranial tumors in terms of total incidence rates. The clinical symptoms presented by the disease are often characterized by a series of systemic endocrine disorders, severe occupational lesions, and even some malignant features, and therefore early diagnosis and predicting recurrence would be instructive for clinical treatment of pituitary adenomas. An increasing number of specific microRNA (miRNA) expression signatures have been identified in pituitary, and miRNAs are related with the pituitary tumorigenesis, dysfunction, neurodegeneration, and metastatic non-functioning pituitary carcinoma. Here, this paper reviews the effects of aberrant miRNA expression in human pituitary adenomas and summarizes some corresponding target genes and biological significance over the last 7 years (2010-2017).
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Article Synopsis
- The study defines anatomical landmarks using preoperative MRI for patients with pituitary adenomas, focusing on how these landmarks relate to tumor resection rates and potential recurrence.
- A review of 626 patients treated via endoscopic endonasal approach was conducted, categorizing anatomical landmarks and utilizing statistical analysis to create a predictive model for surgical outcomes.
- Results showed a high gross total resection rate of 91.05%, identifying key anatomical landmarks and factors significantly associated with tumor progression, supported by a strong predictive model's accuracy.
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