Understanding the structure of an antigen can guide the design of improved antigen-based vaccines.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5774897 | PMC |
| http://dx.doi.org/10.7554/eLife.34087 | DOI Listing |
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Article Synopsis
- Bacterial ghosts (BGs) are promising candidates for vaccine delivery due to their natural ability to enhance immune responses and effectively deliver antigens.
- In this study, researchers modified an E. coli ghost with a protective antigen from Chlamydia abortus, which boosted the ghost's ability to present the antigen to immune cells and activate them.
- The modified ghosts showed improved immune responses in a mouse model, leading to better clearance of Chlamydia abortus infections and less damage to the uterus, suggesting a potential for developing a universal adjuvant-free vaccine platform.
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