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Moth-eye mimetic cytocompatible bactericidal nanotopography: a convergent design. | LitMetric

Moth-eye mimetic cytocompatible bactericidal nanotopography: a convergent design.

Bioinspir Biomim

Madrid Institute for Advanced Studies in Nanoscience (IMDEA Nanoscience), C/Faraday 9, Ciudad Universitaria de Cantoblanco, Madrid 28049, Spain.

Published: February 2018

AI Article Synopsis

  • Antibiotic-resistant bacteria are becoming a major health issue, necessitating innovative methods to fight infections, such as bioinspired surface designs.* -
  • This study highlights a moth-eye mimetic surface created using thermal polymer nanoimprinting, which effectively kills both Gram negative and Gram positive bacteria through physical disruption of bacterial walls.* -
  • The surface also demonstrated good cytocompatibility, supporting healthy growth of keratinocytes, making it a promising option for medical implants that require antibacterial properties alongside biocompatibility.*

Article Abstract

The rapid emergence of antibiotic resistant bacteria has prompted the need for radically different approaches to combat bacterial infections. Among these, bioinspired surface topographies have emerged as an effective sustainable strategy to deter bacterial infection. This study demonstrates the bactericidal activity and cytocompatibility of the moth-eye mimetic topography produced by thermal polymer nanoimprinting. The moth-eye topography was found to have bactericidal capabilities against Gram negative and Gram positive bacteria. Electron microscopy imaging revealed the bactericidal effect caused by mechanical rupture of the bacteria wall inflicted by the topography on the adhered cells. The cytocompatibility of the surfaces was evidenced by assessing the proliferation and morphology of keratinocytes cultured on the nanotopography. The technology meets important needs in medical implant technology for materials that not only have good biocompatibility but also antibacterial properties for reducing the risk of infections and related health complications.

Download full-text PDF

Source
http://dx.doi.org/10.1088/1748-3190/aaa903DOI Listing

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