Caloinophyllin A, a new chromanone derivative from Calophyllum inophyllum roots.

Nat Prod Res

a Faculty of Science, Department of Chemistry, Center of Excellence in Natural Products Chemistry , Chulalongkorn University, Bangkok , Thailand.

Published: November 2018

A new chromanone derivative, namely caloinophyllin A (1), along with eight known compounds (2-9), nobiletin (2), pentamethylquercetin (3), 3,5,7,4'-tetramethoxyflavone (4), 5,7,4'-trimethoxyflavone (5), 1,5-dihydroxyxanthone (6), 1,8-dimethoxy-2-hydroxyxanthone (7), 1,6-dihydroxy-7-methoxyxanthone (8) and 4-methoxycaffeic acid (9) were isolated from the roots of Calophyllum inophyllum. The structures of all the isolated compounds (1-9) were fully characterised using spectroscopic data, as well as comparison with the previous literature data. In addition, the quantum chemical calculation has been used to confirm the conformation of 1. Moreover, all isolated compounds were assessed for their in vitro cytotoxicity against five human cancer cell lines.

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Source
http://dx.doi.org/10.1080/14786419.2018.1425845DOI Listing

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