AI Article Synopsis
- The study investigated the relapse patterns of childhood acute leukemia in 83 children after more than three years of continuous remission before randomizing for therapy continuation or cessation.
- Of the 83 participants, 22.9% (20 children) experienced relapses, with the majority occurring in the bone marrow, central nervous system, and testes.
- The data revealed that males who stopped therapy had a significantly higher relapse rate in the testes (41.1%) compared to those who continued therapy (8.7%), suggesting that ongoing treatment may reduce the risk of relapse in this area.
Article Abstract
The "late" relapse patterns of childhood acute leukemia were studied in 83 children in their first continuous complete remission for more than three years prior to randomization for stopping therapy (40 patients) or continuing therapy (43 patients) for a total of six years. Twenty of 83 (22.9%) have relapsed: Ten in the bone marrow, one in the central nervous system, and nine in the testes. The testes relapse rate of 41.1% (7/17) in males discontinuing therapy at three years was much higher than that of 8.7% (2/23) in males continuing therapy. This difference is significant at P = 0.01 (Wilcoxon test).
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| http://dx.doi.org/10.1002/mpo.2950070105 | DOI Listing |
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