AI Article Synopsis
- The study focused on creating a library of natural products derived from marine microbial cultures to screen for potential drugs.
- Through techniques like UPLC TOF-MS and biological testing, researchers identified a new antibiotic named JBIR-150 from a marine actinomycete Streptomyces sp., isolated from Okinawa.
- The structure of the antibiotic was established using NMR and mass spectrometry, and it showed moderate cytotoxic effects against certain cancer cell lines.
Article Abstract
During the course of constructing a natural product library for drug screening consisting of microbial culture extracts originated from marine samples, we evaluated natural product components profiles via UPLC TOF-MS and routine biological tests for cytotoxic and antibiotic activities for all of the culture extract samples. By combination of chemical screening and biological activities, we succeeded in discovering a 20-membered macrolactam antibiotic subsequently designated JBIR-150 (1) from a marine-derived actinomycete identified as Streptomyces sp. that was isolated from an Okinawan marine sediment. The chemical structure of 1 was determined by interpreting NMR spectroscopic and mass spectrometric data. Compound 1 exhibited moderate cytotoxicity against MESO-1 and Jurkat cells.
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| http://dx.doi.org/10.1038/s41429-017-0010-2 | DOI Listing |
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