AI Article Synopsis
- Aberrant levels of HOXC6 are linked to various malignant tumors, particularly hepatocellular carcinoma (HCC), and are associated with more severe disease features like higher AFP levels, liver cirrhosis, and larger tumors.
- Kaplan-Meier analysis indicates that HOXC6 expression is an independent predictor for overall survival and time to recurrence, and it retains prognostic value across different invasiveness levels and risk subgroups.
- HOXC6 may enhance HCC invasiveness through the epithelial-mesenchymal transition (EMT) process, with studies showing that knocking down HOXC6 reduces cell migration and changes EMT marker expression, confirming its role in poor prognosis for HCC patients.
Article Abstract
Aberrant expression of HOXC6 has been reported in several malignant tumors, yet little is known about the value of HOXC6 in invasion and prognosis of hepatocellular carcinoma (HCC). HOXC6 expression was positively correlated with high AFP level, liver cirrhosis, larger tumor, vascular invasion and BCLC stage. Kaplan-Meier analysis revealed that HOXC6 was an independent predictor for overall survival (OS) and time to recurrence (TTR). In addition, HOXC6 status could act as prognostic predictor in different risk subgroups. Moreover, HOXC6 maintained its prognostic value in different ability of invasiveness. Furthermore, combination of HOXC6 and serum AFP could be a potential predictor for survival in HCC patients. Additionally, further study showed that HOXC6 may promote invasion of HCC by driving epithelial-mesenchymal transition (EMT). Knockdown of HOXC6 significantly decreased the migration and invasion of HCC cells and changed the expression pattern of EMT markers. An opposite expression pattern of EMT markers was observed in HOXC6-transfected cells. In addition, immunohistochemistry and RT-PCR results further confirmed this correlation. In conclusion, HOXC6 contributes to invasion by inducing EMT pathway and predicts poor prognosis of HCC. HOXC6/AFP expression may help to distinguish the different risks of HCC patients after hepatectomy.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5811246 | PMC |
| http://dx.doi.org/10.18632/aging.101363 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
HDAC and MEK inhibition synergistically suppresses HOXC6 and enhances PD-1 blockade efficacy in BRAF-mutant microsatellite stable colorectal cancer.
J Immunother Cancer
January 2025
Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Gastrointestinal Surgery III, Peking University Cancer Hospital & Institute, Beijing, China
Background: B-Raf proto-oncogene, serine/threonine kinase (BRAF)-mutant microsatellite stable (MSS) colorectal cancer (CRC) constitutes a distinct CRC subgroup, traditionally perceived as minimally responsive to standard therapies. Recent clinical attempts, such as BRAF inhibitors (BRAFi) monotherapy and combining BRAFi with other inhibitors, have yielded unsatisfactory efficacy. This study aims to identify a novel therapeutic strategy for this challenging subgroup.
View Article and Find Full Text PDFA conserved sequence that sparked the field of evo-devo.
Dev Biol
February 2025
Entomology Department and Graduate Program in Molecular & Cell Biology, 4291 Fieldhouse Drive, University of Maryland, College Park, MD, 20742, USA.
The discovery that homeotic genes in Drosophila are conserved and utilized for embryonic development throughout the animal kingdom, including humans, revolutionized the fields of developmental biology and evolutionary developmental biology (evo-devo). In a pair of back-to-back papers published in Cell in 1984, researchers at the Biozentrum in Basel, Switzerland, showed that the homeobox - previously identified as a sequence shared by homeotic genes in Drosophila - was also present in the genome of diverse animals. The first paper (McGinnis et al.
View Article and Find Full Text PDFRole of disulfidptosis in colorectal adenocarcinoma: implications for prognosis and immunity.
Front Immunol
October 2024
Department of Gastroenterology, Baiyun Branch, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Article Synopsis
- Recent research discovered a new cell death mechanism called disulfidptosis, which is triggered by disulfide stress in conditions like glucose starvation, particularly in cells with increased SLC7A11 expression.
- This study employed bioinformatics to analyze disulfidptosis-related genes in colorectal cancer (COAD), identifying two distinct molecular subtypes and creating a prognosis risk model based on seven key genes.
- The study ultimately revealed that patient outcomes could be predicted by classifying them into high-risk and low-risk groups based on the expression of these genes, with further analyses providing insights into immune response and treatment options.
Exploring the prognosis value, immune correlation, and drug responsiveness prediction of homeobox C6 (HOXC6) in lung adenocarcinoma.
Discov Oncol
August 2024
Department of Health Management, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People's Republic of China.
Backgrounds: Homeobox C6 (HOXC6) is a gene that encodes for a transcription factor involved in various cellular processes, including development and differentiation, and regulates cancer progression. However, the carcinogenesis and effect of HOXC6 in lung adenocarcinoma (LUAD) still need further investigation.
Methods: The differential HOXC6 expression levels at the mRNA and protein level were explored in multiple public datasets, including The Cancer Genome Atlas (TCGA) and Human Protein Atlas (HPA) dataset.
[Mechanism of HOXC6 promoting the progression of prostate cancer by activating the SFRP1/Wnt/β-catenin signaling pathway].
Zhonghua Nan Ke Xue
July 2024
Department of Urology, Punan Hospital of Shanghai Pudong New Area, Shanghai 200125, China.
Objective: To study the expression of the Homeobox C6 (HOXC6) gene in the homeobox family in PCa, its effect on the biological behavior of PCa cells and its action mechanism.
Methods: Based on the studies of HOXC6 retrieved from the database of Gene Expression Profiling Interactive Analysis (GEPIA), we analyzed the expression of HOXC6 in PCa and the relationship of its expression level with the survival prognosis of the patients. We detected the expression of the HOXC6 protein in PCa tissues and cells by Western blot, stably interfered with the expression of the HOXC6 gene in human PCa DU145 and PC-3 cells and normal prostatic epithelial RWPE-1 cells using the siRNA plasmid, and determined the effects of HOXC6 on the proliferation, migration and invasiveness of PCa cells by CCK8, plate cloning and scratch healing and Transwell invasion assays.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!