Background: a freshwater fish Ophiocephalus striatus or known locally to Indonesian as haruan,can potentially increases IGF-1 and albumin levels in elderly patients with hypoalbuminemia due to the contents of amino acids, fatty acids, vitamins, and minerals. This study was conducted to investigate the effect of Ophiocephalus striatus extract on the level of IGF-1 and albumin in elderly patients with hypoalbuminemia.
Methods: the study is a double-blind randomized controlled trial involving malnourished elderly inpatients (≥60 years old) recovering from acute condition before hospital discharge, with Mini Nutritional Assessment score ≤23.5 and albumin level <3.5 g/dL. A total of 109 subjects were randomly divided into two groups: one group received 10 g Ophiocephalus striatus extract per day for 14 days and another group received placebo. Albumin and IGF-1 levels were obtained before and after intervention.
Results: ninety subjects completed the study (extract group=45 subjects; placebo group =45 subjects) for 14 days. The median of age were 69 (64;75) years and the male to female ratio were 2 : 3. The changes of IGF-1 and albumin levels from before to after intervention between extract group compared to placebo group were 14.7 (0.30;31.5) ng/mL vs 1.0 (-6;13.15) ng/mL (p=0.002) and 0.5 (0.15;0.70) g/dL vs 0.10 (0.0;0.50) g/dL (p=0.003), respectively. There were significant differences in the improvement of IGF-1 and albumin levels between extract and placebo group.
Conclusion: supplementation of Ophiocephalus striatus extract was associated with a significant increase in IGF-1 and albumin levels in elderly patients with hypoalbuminemia.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Extract Supplementation Decreases Serum IL-6 Levels in Older People with Sarcopenia-A Single-Center Experience.
Geriatrics (Basel)
March 2024
Internal Medicine Department, Faculty of Medicine, Gajah Mada University, Yogyakarta 55281, Indonesia.
Sarcopenia, a condition characterized by muscle loss and decreased function in older adults, is a growing public health concern. This study aimed to investigate the effects of extract on insulin-like growth factor-1 serum, interleukin-6 serum levels, and sarcopenia-related parameters in older adults with sarcopenia. This double-blind randomized controlled trial included 80 older adults with sarcopenia.
View Article and Find Full Text PDFInvestigating fish contamination scenario and community willingness to adopt consumption advice proposing an advisory option.
Environ Sci Pollut Res Int
April 2022
Institute for Environment and Development (LESTARI), Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia.
Consumption advice to ensure the health and safety of fish consumers remains urgent to handle the ever-increasing panic over heavy metal toxicity. Moreover, studies of fish consumption rarely focus on the perceptions and awareness of consumers. Considering this, the present study examines the factors determining the willingness to follow fish consumption advice as well as calculate the risk-benefit ratio and produce the vulnerability map followed by formulating fish consumption advice for consumers of two commercially important fish species, tilapia (Oreochromis niloticus) and mudfish (Ophiocephalus striatus), in the Laguna de Bay area of the Philippines.
View Article and Find Full Text PDFPhylogenetic analysis of (Acanthocephala: Quadrigyridae) infecting snakehead murrel in Himachal Pradesh, India.
J Parasit Dis
September 2021
Parasitology Laboratory, Department of Zoology, Panjab University, Chandigarh, 160014 India.
Till date 34 species of have been validated with almost negligible studies on its molecular phylogeny. The discovered species of the genus are confined only to the Asian continent. Many different species of Acanthocephala infecting commercially important freshwater as well as the marine fishes have been recorded from India mainly on the basis of morphology.
View Article and Find Full Text PDFThe Effect of Ophiocephalus striatus Extract on the Levels of IGF-1 and Albumin in Elderly Patients with Hypoalbuminemia.
Acta Med Indones
October 2017
Department of Internal Medicine, Faculty of Medicine, Andalas University, Padang, Sumatera Barat, Indonesia.
Background: a freshwater fish Ophiocephalus striatus or known locally to Indonesian as haruan,can potentially increases IGF-1 and albumin levels in elderly patients with hypoalbuminemia due to the contents of amino acids, fatty acids, vitamins, and minerals. This study was conducted to investigate the effect of Ophiocephalus striatus extract on the level of IGF-1 and albumin in elderly patients with hypoalbuminemia.
Methods: the study is a double-blind randomized controlled trial involving malnourished elderly inpatients (≥60 years old) recovering from acute condition before hospital discharge, with Mini Nutritional Assessment score ≤23.
The role of VipAlbumin(®) as an immunostimulatory agent for controlling homeostasis and proliferation of lymphoid cells.
Cent Eur J Immunol
April 2016
Biology Department, Brawijaya University, Malang, Indonesia.
VipAlbumin(®) is a supplement from snakehead fish (Ophiocephalus striatus) which has high content of albumin that is very important to develop new cells. The aims of this study were to know the effect of VipAlbumin(®) to cell proliferation, expression level of CD4(+)CD62L(+) T cell, regulatory T cell, and B220+ cell, and immunocompetent cell cycle. Cell isolated from spleen of pathogen free mice were cultured in RPMI 1640 with 10% FBS, 1% Pen/Strep 10×, 2-Mercaptoetanol, anti-CD3 and LPS.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!