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Synthesis, optimization and biological evaluation of 99mTc-digoxin as possible cardiac imaging agent. | LitMetric
Heart imaging radiopharmaceuticals could improve the diagnostic value of routine heart scanning for detecting cardiac disorders. The aim of the study was to prepare high radiochemical purity 99mTc-Digoxin in a yield of about 98%. The optimal conditions for labelling were as follows: 100μg of Digoxin, 2μg of SnCl2 •2H2 O, room temperature (25±1°C), reaction retention time of 30 min at pH 7. Under these conditions, the radiochemical yield of Tc-Digoxin reaches 98%. In vivo bio distribution was performed in normal Swiss Albino mice at different time intervals after administration of Tc-Digoxin.Scintigraphic study of Tc-Digoxin was performed in rabbits. The heart uptake of Tc-Digoxin was sufficiently high and thus may be a potential myocardial imaging radiopharmaceutical applicable in cardiology.
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