AI Article Synopsis
- A new indole alkaloid named bacilsubteramide A was isolated from the deep-sea bacterium Bacillus subterraneus 11593, alongside three known compounds.
- Detailed NMR spectroscopic analysis and theoretical ECD calculations were used to determine the absolute configuration of bacilsubteramide A as (R)-N-[2-(3-hydroxy-2-oxoindolin-3-yl)ethyl]acetamide.
- All four compounds, including the new alkaloid, were tested for anti-allergic activity but showed no significant effect with IC values higher than 0.2 mM, marking the first report of secondary metabolites from this bacterium.
Article Abstract
From the deep-sea-derived bacterium Bacillus subterraneus 11593, a new indole alkaloid (1) was isolated along with three known compounds (2‒4). By detailed analysis of its NMR spectroscopic data, and further by the theoretical ECD calculations, the absolute configuration of the new compound was determined to be (R)-N-[2-(3-hydroxy-2-oxoindolin-3-yl)ethyl]acetamide, and named bacilsubteramide A. All four isolates were tested for anti-allergic bioactivities; however, none exhibited positive effect (IC > 0.2 mM). Noteworthily, it is the first report on secondary metabolites from the bacterium B. subterraneus.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/14786419.2018.1425852 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!