With the resurgence of tuberculosis (TB), it is imperative that healthcare providers have the necessary skills to manage the specialized issues of prevention, recognition, and treatment of TB. The case study in this article illustrates these skills for NPs and other advanced practice providers.
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Relating ecological diversity to genetic discontinuity across bacterial species.
Genome Biol
January 2025
Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.
Background: Genetic discontinuity represents abrupt breaks in genomic identity among species. Advances in genome sequencing have enhanced our ability to track and characterize genetic discontinuity in bacterial populations. However, exploring the degree to which bacterial diversity exists as a continuum or sorted into discrete and readily defined species remains a challenge in microbial ecology.
View Article and Find Full Text PDFClinical Pharmacokinetics of Antitubercular Drugs in the Overweight and Obese Population: Implications for Dosage Adjustments.
Clin Pharmacokinet
January 2025
Department of Clinical Pharmacology, Medical University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria.
The rise in global obesity prevalence has increased the need to understand the pharmacokinetics of drugs in overweight and obese individuals. Tuberculosis remains a significant health challenge, and its treatment outcomes can be influenced by the pharmacokinetic profiles of antitubercular agents. This literature review aims to point out the clinical pharmacokinetics of antitubercular drugs in the overweight and obese patient population, highlighting considerations for potential dosage adjustments.
View Article and Find Full Text PDFImpact of gestational diabetes on depression and breastfeeding self-efficacy in the postpartum period in a selected hospital of Bhubaneswar.
J Family Med Prim Care
December 2024
Department of Obstetric and Gynaecology Nursing, Kalinga Institute of Nursing Sciences, KIIT Deemed to be University, Patia, Bhubaneswar, Odisha, India.
Background: Gestational diabetes mellitus (GDM) is the most common medical complication and metabolic disorder of pregnancy. The prevalence of GDM in all pregnancies is approximately 7%. Globally, there are 14% pregnancies with significant variability in prevalence based on diagnostic criteria, sociodemographic characteristics, and geographic region.
View Article and Find Full Text PDFA Highly Divergent Mitochondrial Genome in Extant Cape Buffalo From Addo Elephant National Park, South Africa.
Ecol Evol
January 2025
Molecular Ecology and Evolution Programme, Department of Biochemistry, Genetics and Microbiology University of Pretoria Pretoria South Africa.
The reduced cost of next-generation sequencing (NGS) has allowed researchers to generate nuclear and mitochondrial genome data to gain deeper insights into the phylogeography, evolutionary history and biology of non-model species. While the Cape buffalo () has been well-studied across its range with traditional genetic markers over the last 25 years, researchers are building on this knowledge by generating whole genome, population-level data sets to improve understanding of the genetic composition and evolutionary history of the species. Using publicly available NGS data, we assembled 40 Cape buffalo mitochondrial genomes (mitogenomes) from four protected areas in South Africa, expanding the geographical range and almost doubling the number of mitogenomes available for this species.
View Article and Find Full Text PDFBreaking the energy chain: importance of ATP synthase in and its potential as a drug target.
RSC Med Chem
January 2025
Infectious Diseases Division, CSIR - Indian Institute of Integrative Medicine Jammu-180001 India
Unveiling novel pathways for drug discovery forms the foundation of a new era in the combat against tuberculosis. The discovery of a novel drug, bedaquiline, targeting mycobacterial ATP synthase highlighted the targetability of the energy metabolism pathway. The significant potency of bedaquiline against heterogeneous population of marks ATP synthase as an important complex of the electron transport chain.
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