AI Article Synopsis
- * Dysfunction of NATs has been linked to human diseases, including cancers, neurodegenerative disorders, and cardiovascular issues, highlighting their significance in health and disease.
- * The review discusses the potential of oligonucleotide-based therapies targeting NATs, evaluating both their benefits and drawbacks while highlighting advancements in this emerging area of clinical research.
Article Abstract
Antisense transcription is a widespread phenomenon in mammalian genomes, leading to production of RNAs molecules referred to as natural antisense transcripts (NATs). NATs apply diverse transcriptional and post-transcriptional regulatory mechanisms to carry out a wide variety of biological roles that are important for the normal functioning of living cells, but their dysfunctions can be associated with human diseases. In this review, we attempt to provide a molecular basis for the involvement of NATs in the etiology of human disorders such as cancers and neurodegenerative and cardiovascular diseases. We also discuss the pros and cons of oligonucleotide-based therapies targeted against NATs, and we comment on state-of-the-art progress in this promising area of clinical research. WIREs RNA 2018, 9:e1461. doi: 10.1002/wrna.1461 This article is categorized under: RNA in Disease and Development > RNA in Disease Regulatory RNAs/RNAi/Riboswitches > Regulatory RNAs RNA Interactions with Proteins and Other Molecules > Small Molecule-RNA Interactions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5838512 | PMC |
| http://dx.doi.org/10.1002/wrna.1461 | DOI Listing |
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