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| http://dx.doi.org/10.1016/j.ekir.2017.08.004 | DOI Listing |
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ADENOVIRUS PNEUMONITIS AND DISSEMINATED VIREMIA IN A NEONATE SUCCESSFULLY TREATED WITH STEROIDS, CIDOFOVIR AND ECMO.
Pediatr Infect Dis J
December 2024
From the Department of Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
A 5-day-old neonate was admitted with chest radiograph showing right-lung opacification. This, together with a severe adenovirus (AdV) viremia (11.8 million copies/mL), indicated severe adenovirus pneumonitis.
View Article and Find Full Text PDFArticle Synopsis
- Adenovirus infections are particularly dangerous for immunocompromised individuals, with no FDA-approved treatment currently available, leading to the off-label use of cidofovir which has kidney toxicity.
- Research has shown that USC-093, an orally administered prodrug, is effective against adenovirus in hamsters, showing less nephrotoxicity compared to traditional treatments.
- The study details the synthesis of USC-093 and its D-homoserinamide analogue, finding that both have significantly higher potency against adenoviruses compared to cidofovir, particularly highlighting the benefits of USC-093D in terms of efficacy.
The Outcomes of Adenovirus Infection in Kidney Transplant Recipients.
Transpl Infect Dis
November 2024
Division of Nephrology, Mayo Clinic, Phoenix, Arizona, USA.
Background: Adenovirus (ADV) infection can lead to significant morbidity and mortality in immunocompromised patients, particularly in those with hematopoietic stem cells or solid organ transplants. The incidence of ADV infection in kidney transplant (KT) is not well-defined as ADV is often asymptomatic and not routinely checked.
Methods: This retrospective case-series study included KT and simultaneous pancreas-KT (SPKT) recipients from January 1, 2008, to January 31, 2024, across three Mayo Clinic sites (Arizona, Florida, and Minnesota) with symptomatic adenovirus polymerase chain reaction cases.
Wastewater-associated plastispheres: A hidden habitat for microbial pathogens?
PLoS One
November 2024
Faculty of Veterinary Medicine, Virology Unit, Norwegian University of Life Sciences, Ås, Norway.
Wastewater treatment plants (WWTPs) receive wastewater from various sources. Despite wastewater treatment aiming to remove contaminants, microplastics persist. Plastic surfaces are quickly colonized by microbial biofilm ("plastispheres").
View Article and Find Full Text PDFNon-hepatotropic viral hepatitis: a narrative review.
Scand J Gastroenterol
December 2024
Infectious Diseases, St. Joseph's University Medical Center, Paterson, NJ, USA.
Article Synopsis
- * Unlike well-researched hepatotropic viruses (hepatitis A-E), research on NHVH is limited due to its rarity and generally mild symptoms.
- * NHVH can present as mild liver enzyme elevations or lead to severe acute liver failure, and management often focuses on understanding the specific virus involved.
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