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| http://dx.doi.org/10.18632/oncotarget.22717 | DOI Listing |
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Lidocaine Enhanced Antitumor Efficacy and Relieved Chemotherapy-Induced Hyperalgesia in Mice with Metastatic Gastric Cancer.
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Department of Anaesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
With the widespread use of lidocaine for pain control in cancer therapy, its antitumor activity has attracted considerable attention in recent years. This paper provides a simple strategy of combining lidocaine with chemotherapy drugs for cancer therapy, aiming to relieve chemotherapy-induced pain and achieve stronger antitumor efficacy. However, there is still a lack of substantial pre-clinical evidence for the efficacy and related mechanisms of such combinations, obstructing their potential clinical application.
View Article and Find Full Text PDFCardiotoxicity of Chemotherapy: A Multi-OMIC Perspective.
J Xenobiot
January 2025
VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium.
Chemotherapy-induced cardiotoxicity is a critical issue in cardio-oncology, as cancer treatments often lead to severe cardiovascular complications. Approximately 10% of cancer patients succumb to cardiovascular problems, with lung cancer patients frequently experiencing arrhythmias, cardiac failure, tamponade, and cardiac metastasis. The cardiotoxic effects of anti-cancer treatments manifest at both cellular and tissue levels, causing deformation of cardiomyocytes, leading to contractility issues and fibrosis.
View Article and Find Full Text PDFAssociation analysis of genetic polymorphisms of METTL3 with clinical outcomes in a Chinese pediatric population with primary brain tumors.
Gene
March 2025
Department of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. Electronic address:
Background: Methyltransferase-like 3 (METTL3) regulates numerous biological processes and diverse cancers.
Objective: To explore the frequency distribution of METTL3 rs1061026, rs1139130, and rs1263801 polymorphisms, and their potential impacts on clinical outcomes and chemotherapy-induced toxicities in a cohort of Chinese pediatric patients diagnosed with primary brain tumors (PBTs).
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Chemotherapy-Induced Cell-Surface GRP78 Expression as a Prognostic Marker for Invasiveness of Metastatic Triple-Negative Breast Cancer.
Ann Biomed Eng
January 2025
Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, 3200003, Haifa, Israel.
Article Synopsis
- Metastasis is responsible for 90% of cancer-related deaths, particularly in triple-negative breast cancer (TNBC), making it essential to understand molecular drivers to find better prognostic markers after chemotherapy.
- Current chemotherapy treatments like doxorubicin and paclitaxel affect tumor cells in various ways, including activating the unfolded protein response (UPR), with GRP78 playing a significant but controversial role in metastasis.
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Nanomedicine based on chemotherapy-induced immunogenic death combined with immunotherapy to enhance antitumor immunity.
Front Pharmacol
December 2024
Department of Breast Surgery, General Surgery Center of The First Hospital, Jilin University, Changchun, China.
Introduction: Chemo-immunotherapy based on inducing tumor immunogenic cell death (ICD)with chemotherapy drugs has filled the gaps between traditional chemotherapy and immunotherapy. It is verified that paclitaxel (PTX) can induce breast tumor ICD. From this basis, a kind of nanoparticle that can efficiently deliver different drug components simultaneously is constructed.
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