The paper reports the results obtained by percutaneous transluminal angioplasty (PTA) in the treatment of renal artery stenosis in 25 patients with secondary hypertension and discusses indications and the technique used. The follow-up period ranged from 0.5 to 12 months. All interventions were performed with the Olbert catheter system. Following PTA a significant decrease in systolic, diastolic and mean arterial pressure was observed in nearly all patients. The response of the plasma renin activity (PRA) to orthostatic stimulation and pharmacological stimulation by furosemide was determined in a subset of 15 patients before and after PTA. A significant decrease in both basal and stimulated PRA values was observed subsequent to PTA. The decrease in PRA values after successful PTA did not, however, correlate with the extent of the blood pressure changes.
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Article Synopsis
- The study investigated how different treatments (balloon angioplasty vs. drug-coated balloons) affect the changes in blood vessel tissues following arteriovenous fistula stenosis in pigs with chronic kidney disease.
- Significant differences in tissue composition were observed, with drug-coated balloons leading to lower neointimal growth and higher endothelial cell counts compared to standard angioplasty.
- The findings suggest that using drug-coated balloons may improve vessel healing and reduce complications over time, as shown by varied immune cell responses and tissue growth patterns.
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