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Nitro-fatty acids: promising agents for the development of new cancer therapeutics.
Trends Pharmacol Sci
November 2024
Division of Immunology, Paul-Ehrlich-Institute, Federal Institute for Vaccines and Biomedicines, Langen, 63225, Hesse, Germany.
Nitro-fatty acids (NO-FAs) are endogenous pleiotropic lipid mediators regarded as promising drug candidates for treating inflammatory and fibrotic diseases. Over the past two decades, the anti-inflammatory and cytoprotective actions of NO-FAs and several molecular targets have been identified. More recently, preclinical studies have demonstrated their potential as prospective cancer therapeutics with favorable safety and tumor-selective profiles.
View Article and Find Full Text PDFCombined systemic inflammatory immune index and prognostic nutrition index as chemosensitivity and prognostic markers for locally advanced gastric cancer receiving neoadjuvant chemotherapy: a retrospective study.
BMC Cancer
August 2024
Research Center and Tumor Research Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei, China.
Article Synopsis
- The study investigates the combined impact of the Prognosis Nutritional Index (PNI) and Systemic Inflammatory Immunological Index (SII) on predicting tumor response and prognosis in patients with locally advanced gastric cancer (LAGC) after chemotherapy.
- A retrospective analysis of 181 LAGC patients was conducted, categorizing them into tumor regression grade (TRG) 3 and non-TRG3 groups, and assessing their SII and PNI values.
- Results showed that higher SII-PNI scores were linked to better tumor responses and poorer overall and disease-free survival, indicating the SII-PNI score could be a useful predictor in clinical settings.
The role and mechanism of IFITM1 in developing acquired cisplatin resistance in small cell lung cancer.
Heliyon
May 2024
Department of Oncology, The Sixth Affiliated Hospital of Kunming Medical University, China.
Platinum-based chemotherapies, historically the cornerstone of first-line treatment for small-cell lung cancer (SCLC), face a major hurdle: the frequent emergence of chemoresistance, notably to cisplatin (CDDP). Current understanding of the mechanisms driving CDDP resistance in SCLC is incomplete. Notably, Interferon inducible transmembrane protein1 (IFITM1) has been identified as a key player in the distant metastasis of SCLC.
View Article and Find Full Text PDF(Single-stranded DNA) gaps in understanding BRCAness.
Trends Genet
September 2024
Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands; Oncode Institute, Utrecht, The Netherlands. Electronic address:
The tumour-suppressive roles of BRCA1 and 2 have been attributed to three seemingly distinct functions - homologous recombination, replication fork protection, and single-stranded (ss)DNA gap suppression - and their relative importance is under debate. In this review, we examine the origin and resolution of ssDNA gaps and discuss the recent advances in understanding the role of BRCA1/2 in gap suppression. There are ample data showing that gap accumulation in BRCA1/2-deficient cells is linked to genomic instability and chemosensitivity.
View Article and Find Full Text PDFCurrent Trends on the Involvement of Zinc, Copper, and Selenium in the Process of Hepatocarcinogenesis.
Nutrients
February 2024
Department of Gastroenterology and Neurology, Faculty of Medicine, Kagawa University, 1750-1, Ikenobe, Miki-cho 761-0793, Kagawa, Japan.
Numerous nutritional factors increase the risk of hepatocellular carcinoma (HCC) development. The dysregulation of zinc, copper, and selenium homeostasis is associated with the occurrence of HCC. The impairment of the homeostasis of these essential trace elements results in oxidative stress, DNA damage, cell cycle progression, and angiogenesis, finally leading to hepatocarcinogenesis.
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