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Inorganic Mercury Pharmacokinetics in Man: A Hybrid Model.
Xenobiotica
January 2025
Department of Pharmaceutical Sciences, School of Pharmacy, Westcoast University, 590 North Vermont Avenue, Los Angeles, CA 90004.
A four-compartment model is presented that simulates inorganic mercury [Hg(II)] pharmacokinetics in blood, tissue, and excreta over a 70 day period. Simulations are validated against data collected from five human subjects, and previously analyzed (Farris, F.F.
View Article and Find Full Text PDFResistant starch inhibits high-fat diet-induced oncogenic responses in the colon of C57BL/6 mice.
J Nutr Biochem
January 2025
United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota 58203.
The beneficial effects of dietary fiber for colon health may be due to short chain fatty acids (SCFAs), such as butyrate, produced by colonic bacterial fermentation. In contrast, obesogenic diet induced obesity is linked to increased colon cancer incidence. We hypothesize that increasing fiber intake promotes healthy microbiome and reduces bacterial dysbiosis and oncogenic signaling in the colon of mice fed an obesogenic diet.
View Article and Find Full Text PDFAsparagopsis taxiformis supplementation to mitigate enteric methane emissions in dairy cows - effects on performance and metabolism.
J Dairy Sci
January 2025
Department of Applied Animal Science & Welfare, Swedish University of Agricultural Sciences (SLU), Box 7024, 753 23 Uppsala, Sweden.
Methane emissions from ruminant digestion contribute significantly to global anthropogenic greenhouse gas emissions. Members of the phylum Rhodophyta (red algae), particularly Asparagopsis sp., have shown promising results in reducing methane emissions in ruminants, due to their high content of halogenated methane analog compounds.
View Article and Find Full Text PDF[Role of human herpesvirus infection in refractory gastrointestinal graft-versus-host-disease after hematopoietic stem cell transplantation and the diagnosis and treatment thereof].
Zhonghua Xue Ye Xue Za Zhi
November 2024
Department of Bone Marrow Transplantation, Hebei Yanda Lu Daopei Hospital, Langfang 065300, China.
This study aimed to investigate the role of human herpesvirus (HHV) infection in refractory intestinal graft-versus-host disease (GI-GVHD) after hematopoietic stem cell transplantation (HSCT) and its diagnosis and treatment. This study retrospectively analyzed patients presenting with refractory GI-GVHD after allogeneic HSCT (allo-HSCT) with concomitant colonoscopy and mucosal biopsy at Lu Daopei Hospital, Yanda, Hebei, from March 2022 to July 2024. Human herpesvirus 6 (HHV6), HHV7, cytomegalovirus (CMV), and Epstein-Barr virus (EBV) detection with the RQ-PCR method.
View Article and Find Full Text PDF28-Day Repeated Dose Toxicity and Toxicokinetics Study on Dihydroartemisinin (DHA) in SD Rats.
J Appl Toxicol
December 2024
School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China.
Dihydroartemisinin (DHA) is an effective antimalarial drug with potential antitumor efficacy, yet toxicological information is limited. The present study was designed to evaluate the potential toxicity of oral DHA. DHA was administered orally by gavage to SD rats at doses of 0, 25, 50, and 75/60 mg/kg b.
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