Objectives: This study evaluated the feasibility of measuring the fetal mesencephalon and pons by ultrasonographic cross sectional imaging to detect fetal central nervous system developmental abnormalities.
Materials And Methods: Fetal ultrasonographic measurements included: Fetal mesencephalon anteroposterior diameters (MAD), mesencephalon transverse diameters (MTD), pons anteroposterior diameter (PAD) and proximal transverse diameters (PTD).
Results: Nine-hundred ninety fetuses were imaged. Thirty-eight fetuses (observation group) presented central nervous system abnormalities; 952 fetuses without imaged abnormalities were utilized as the reference (control) group. Fetal MAD, MTD, PAD, and PTD in control fetuses showed a linear correlation with gestational age. Thirty-eight fetuses had 40 abnormal measurements (8 MAD, 8 MTD, 14 PAD, and 10 PTD), 16 in mesencephalon, and 24 in pons. All data fell below the 95% confidence intervals' lower limits for the corresponding gestational age.
Conclusion: Using normative data based on 957 fetuses allows detection of size abnormalities of the pons and midbrain during fetal life.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/15513815.2017.1397069 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
FGF8-mediated gene regulation affects regional identity in human cerebral organoids.
Elife
November 2024
Univ. Côte d'Azur (UniCA), CNRS, Inserm, Institut de Biologie Valrose (iBV), Nice, France.
Article Synopsis
- The study investigates how the morphogen FGF8 affects the development of brain-like structures derived from human stem cells, specifically focusing on its role in establishing cellular diversity and regional identities during early brain development.
- FGF8 treatment led to the formation of various brain regions within the organoids, influencing the identity of neural progenitor cells and the ratio of different types of neurons (GABAergic and glutamatergic).
- The research highlights FGF8's critical role in regulating genes linked to neurodevelopmental disorders, suggesting its potential involvement in both healthy brain development and related pathological conditions.
Advances in prenatal surgical management of congenital aqueductal stenosis: A bench to bedside approach.
Semin Fetal Neonatal Med
November 2024
The Center for Fetal and Placental Research, Cincinnati Fetal Center, Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH, USA. Electronic address:
Congenital aqueduct stenosis AS is a significant cause of fetal obstructive hydrocephalus, characterized by the obliteration of the cerebral aqueduct, leading to cerebrospinal fluid (CSF) accumulation in the ventricular system and secondary brain damage and cerebral maldevelopment. This review explores the progression from basic science to clinical applications of antenatal surgical interventions for AS, emphasizing historical efforts, current research, and translational studies. Despite advances in prenatal imaging and genetic screening, challenges remain in achieving appropriate fetal candidates, consistent ventricular decompression, and standardized surgical protocols.
View Article and Find Full Text PDFSex-Specific ADNP/NAP (Davunetide) Regulation of Cocaine-Induced Plasticity.
J Mol Neurosci
September 2024
The Elton Laboratory for Molecular Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Faculty of Medicine, Sagol School of Neuroscience and Adams Super Center for Brain Studies, Tel Aviv University, Tel Aviv, 6997801, Israel.
Cocaine use disorder (CUD) is a chronic neuropsychiatric disorder estimated to effect 1-3% of the population. Activity-dependent neuroprotective protein (ADNP) is essential for brain development and functioning, shown to be protective in fetal alcohol syndrome and to regulate alcohol consumption in adult mice. The goal of this study was to characterize the role of ADNP, and its active peptide NAP (NAPVSIPQ), which is also known as davunetide (investigational drug) in mediating cocaine-induced neuroadaptations.
View Article and Find Full Text PDFOral pre- and early postnatal cannabis exposure disinhibits ventral tegmental area dopamine neuron activity but does not influence cocaine preference in offspring in mice.
J Neurosci Res
July 2024
Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Article Synopsis
- Cannabis use in Canada rose from 1.5% to 2.5% between 2012 and 2019, prompting studies on prenatal cannabis exposure and its potential impacts on birth weight and neurodevelopment, complicated by various factors.
- Research utilizing animal models, specifically a study with mice, controls for dose and timing by exposing mothers to THC through a peanut butter diet during pregnancy and early postnatal life.
- Findings revealed that male offspring had altered VTA dopamine neuron activity but exhibited no changes in cocaine-seeking behavior, indicating that prenatal cannabis exposure can impact neurodevelopment in a sex-specific manner.
North American Fetal Therapy Network: Maternal Outcomes in Fetal Aqueductal Stenosis.
Fetal Diagn Ther
December 2024
Department of Obstetrics and Gynecology, Riley Children's Hospital, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Introduction: Fetal aqueductal stenosis (AS) affects approximately 1:1,000 pregnancies. Obstruction of cerebral spinal fluid circulation occurs at the aqueduct of Sylvius, leading to progressive hydrocephalus and macrocephaly, which often necessitates cesarean section (CS). The purpose of this study was to describe maternal outcomes associated with fetal AS.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!