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An Automated Tool for Glycosimilarity Assessment of mAb Therapeutic Biosimilars: Trastuzumab and Bevacizumab as Case Studies.
BioDrugs
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Department of Chemical Engineering, Indian Institute of Technology Delhi, New Delhi, India.
Background: With the expiration of patents for multiple biotherapeutics, biosimilars are gaining traction globally as cost-effective alternatives to the original products. Glycosylation, a critical quality attribute, makes glycosimilarity assessment pivotal for biosimilar development. Given the complexity of glycoanalytical profiles, assessing glycosimilarity is nontrivial.
View Article and Find Full Text PDFA reliable and objective method of measuring soft tissue changes in 2D photographs after distraction osteogenesis in individuals with CL/P.
J Plast Surg Hand Surg
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Department of Clinical Sciences in Malmö, Lund University, Lund, Sweden; Department of Oral and Maxillofacial Surgery, Skåne University Hospital, Malmö, Sweden; Department of Orthodontics, Malmö University, Malmö, Sweden.
Pre- and postoperative photos to assess results are widely used in plastic and reconstructive surgery, for instance, in patients with cleft lip and palate (CL/P). Evaluations are often performed by assessment panels by viewing the photos. However, these are prone to be subjective.
View Article and Find Full Text PDFGDFold2: A fast and parallelizable protein folding environment with freely defined objective functions.
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MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing, China.
An important step of mainstream protein structure prediction is to model the 3D protein structure based on the predicted 2D inter-residue geometric information. This folding step has been integrated into a unified neural network to allow end-to-end training in state-of-the-art methods like AlphaFold2, but is separately implemented using the Rosetta folding environment in some traditional methods like trRosetta. Despite the inferiority in prediction accuracy, the conventional approach allows for the sampling of various protein conformations compatible with the predicted geometric constraints, partially capturing the dynamic information.
View Article and Find Full Text PDFEvaluation of the Efficiency of Ultrasonography and Color Doppler in Diagnosis of Intraosseous Jaw Lesions: An Study.
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October 2024
Department of Prosthodontics, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Pune, Maharashtra, India.
Aim: The current investigation aimed to evaluate the accuracy of ultrasonography and color Doppler performed in the diagnosis of intraosseous jaw lesions.
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Spatially explicit estimation of recent migration rates in plants using genotypic data.
Genetics
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Institute of Forest Sciences (ICIFOR-INIA), CSIC, Ctra. De la Coruña km 7.5, 28040 Madrid, Spain.
We present a new hierarchical Bayesian method using multilocus genotypes to estimate recent seed and pollen migration rates in a spatially explicit framework that incorporates distance effects separately for each type of dispersal. The method additionally estimates population allelic frequencies, population divergence values, individual inbreeding coefficients, individual maternal and paternal ancestries, and allelic dropout rates. We conduct a numerical simulation analysis that indicates that the method can provide reliable estimates of seed and pollen migration rates and allow accurate inference of spatial effects on migration, at affordable sample sizes (25-50 individuals/population) when population genetic divergence is not low (FST≥0.
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