Objective: To improve the diagnosis and treatment of Penicilliosis marneffei without human immunodeficiency virus infection.
Methods: Analyze and review the clinical features, diagnosis and treatment of six cases of P. marneffei without human immunodeficiency virus infection at The First Affiliated Hospital of Fujian Medical University.
Results: Two cases were diagnosed in the ENT Department, three cases in the respiratory department and one case in the dermatological department. Penicillium marneffei infection was confirmed by sputum culture, blood culture and tissue biopsy. After definite diagnosis, one refused further treatment, and others showed significant improvement.
Conclusion: Penicilliosis marneffei is insidious onset and easy to be escaped and misdiagnosed. To achieve early diagnosis and appropriate treatment, doubtful cases should be alerted for the diagnoses as P. marneffei.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s11046-017-0236-3 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Talaromyces marneffei, Coccidioides species, and Paracoccidioides species-a systematic review to inform the World Health Organization priority list of fungal pathogens.
Med Mycol
June 2024
Department of Infectious Diseases, The Alfred and Monash University, Melbourne, Victoria, Australia.
Article Synopsis
- The World Health Organization initiated a fungal pathogen priority list due to the rising threat of fungal diseases, focusing on the epidemiology of Talaromyces marneffei, Coccidioides species, and Paracoccidioides species.
- A total of 48 studies were reviewed, revealing high mortality rates for invasive infections (up to 22.7%) and frequent hospitalizations for coccidioidomycosis (up to 84%), often with readmission.
- There is evidence of reduced effectiveness of certain antifungals against some species, with risk factors for mortality related to CD4 counts, and outbreaks commonly linked to construction activities; increased surveillance and further studies are needed.
Dynamic m A profiles reveal the role of YTHDC2-TLR2 signaling axis in Talaromyces marneffei infection.
J Med Virol
February 2024
Life Sciences Institute & Guangxi Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application, Guangxi Medical University, Nanning, Guangxi, China.
Talaromyces marneffei (TM) immune evasion is an important factor leading to the high mortality rate of Penicilliosis marneffei. N -methyladenosine (m A) plays important roles in host immune response to various pathogen infections, yet its role in TM and HIV/TM coinfection remains largely unexplored. Here we reported genome-wide transcriptional m A profiles of TM mono-infection and HIV/TM coinfection.
View Article and Find Full Text PDFImpact of pathogen genetics on clinical phenotypes in a population of Talaromyces marneffei from Vietnam.
Genetics
August 2023
Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Talaromycosis, a severe and invasive fungal infection caused by Talaromyces marneffei, is difficult to treat and impacts those living in endemic regions of Southeast Asia, India, and China. While 30% of infections result in mortality, our understanding of the genetic basis of pathogenesis for this fungus is limited. To address this, we apply population genomics and genome-wide association study approaches to a cohort of 336 T.
View Article and Find Full Text PDFTalaromyces marneffei isolated from nasal swabs in Portugal.
Med Mycol
April 2023
Department of Veterinary Sciences, UTAD, Quinta dos Prados, 5000-801, Vila Real, Portugal.
Mycobiota are essential to the health of any living being, creating a balanced and complex interaction between bacteria, the immune system, and the tissue cells of the host. Talaromyces marneffei (also known as Penicillium marneffei) is a dimorphic fungus, endemic in South Asia, which often causes a life-threatening systemic fungal infection (called penicilliosis), particularly in immunocompromised hosts. Nasal swabs from 73 healthy volunteers were analysed to characterize their mycobiota, through its cultural characteristics, morphology, and molecular methods (PCR).
View Article and Find Full Text PDFPenicilliosis marneffei is an extremely rare fungal infectious disease and is especially rare in people with normal immunity. Penicilliosis marneffei restricted to the lung and involving the formation of a pulmonary tumor is difficult to distinguish from peripheral lung cancer. This kind of case has rarely been reported.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!