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"Utility of PET/CT with [F] F-fluorocholine in assessing the response to antiandrogenic therapy in patients with prostate cancer.".
Rev Esp Med Nucl Imagen Mol (Engl Ed)
January 2025
Servicio de Medicina Nuclear, Hospital Clínic Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS) y Universitat de Barcelona (UB), Barcelona, Spain.
Objective: To evaluate the correlation between response assessment measured by PET/CT with [F] F-fluorocholine (Choline PET/CT) and serum levels of PSA in patients with prostate cancer under antiandrogenic treatment.
Methodology: A retrospective study included patients with CRPC and CSPC treated with enzalutamide, abiraterone, or apalutamide between June 2018 and July 2021, who underwent baseline and a follow-up Choline PET/CT. The difference in maximum SUVmax (ΔSUV) between both studies and the PSA value before and at follow-up were recorded.
[F]fluorocholine PET . [Tc]sestamibi scintigraphy for detection and localization of hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism: outcomes and resource efficiency.
Radiol Oncol
December 2024
Division of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Article Synopsis
- - Minimally invasive parathyroidectomy is the preferred treatment for primary hyperparathyroidism, but it relies on effective preoperative localization methods to identify overactive parathyroid tissue.
- - A study compared two groups of patients—234 who had traditional MIBI scintigraphy and 163 who had FCh-PET/CT—focusing on the efficiency and outcomes of these imaging techniques leading up to surgery.
- - Results showed that FCh-PET/CT significantly reduced imaging time by 83% and surgery time by 41% without using intraoperative hormone monitoring, suggesting it may lead to faster procedures and fewer reoperations for patients.
Bone Mineral Density and First Line Imaging with [F]fluorocholine PET/CT in Normocalcemic and Hypercalcemic Primary Hyperparathyroidism: Results from a Single Center.
Diagnostics (Basel)
November 2024
Department of Nuclear Medicine and Endocrinology, University Hospital Salzburg, Muellner Hauptstrasse 48, 5020 Salzburg, Austria.
: Primary hyperparathyroidism (PHPT) is associated with normal or elevated calcium levels and affects bone mineral density. The proportion of cases predisposed to metabolic bone disease is unknown in patients with PHPT. The aim of this study was to assess bone mineral density and bone quality in patients with normo- or hypercalcemic primary hyperparathyroidism undergoing baseline parathyroid gland assessment with [F]fluorocholine PET/CT imaging.
View Article and Find Full Text PDFF-fluorocholine PET/CT imaging in primary hyperparathyroidism after negative or inconclusive cervical ultrasonography and Tc-MIBI scintigraphy.
Jpn J Radiol
November 2024
Department of Nuclear Medicine and Radiation Protection, University Hospital Centre Zagreb, Kispaticeva 12, 10000, Zagreb, Croatia.
Article Synopsis
- The study investigates the effectiveness of F-fluorocholine PET/CT imaging in locating hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism (pHPT) when other imaging methods were inconclusive.
- Out of 167 patients, F-fluorocholine PET/CT identified 92.81% of lesions, showing high sensitivity and accuracy, leading to successful surgical interventions.
- Post-surgery, patients experienced a significant reduction in parathyroid hormone levels, confirming the imaging's reliability for preoperative planning in pHPT cases.
Diagnostic Performances of F-Fluorocholine PET/CT as First-Line Functional Imaging Method for Localization of Hyperfunctioning Parathyroid Tissue in Primary Hyperparathyroidism.
Acad Radiol
October 2024
Nuclear Medicine Department, Centre Georges François Leclerc, 21000 Dijon, France. Electronic address:
Article Synopsis
- This study assessed the effectiveness of F-fluorocholine (FCH) PET/CT for locating hyperfunctioning parathyroid glands in patients with primary hyperparathyroidism (PHPT) before surgery.
- The research involved 80 patients who underwent FCH PET/CT, comparing the imaging results with histological findings and postoperative outcomes to evaluate the method's diagnostic performance.
- Results showed that FCH PET/CT had a sensitivity of 88% and a positive predictive value of 91%, indicating it is a valuable tool for pre-surgical localization of problematic parathyroid tissue in PHPT patients.*
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