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Interstitial lung diseases with concomitant lung cancer: a data mining approach revealing a complex condition with gender- and immune-associated specific implications.
Front Oncol
December 2024
Department of Internal Medicine and Medical Therapeutics, University of Pavia Medical School, Pavia, Italy.
Background: Interstitial lung diseases (ILDs) comprise a family of heterogeneous entities, primarily characterised by chronic scarring of the lung parenchyma. Among ILDs, idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pneumonitis, associated with progressive functional decline leading to respiratory failure, a high symptom burden, and mortality. Notably, the incidence of lung cancer (LC) in patients already affected by ILDs-mainly IPF-is significantly higher than in the general population.
View Article and Find Full Text PDFAssociations between health, productive performance and oral fluid biomarkers in commercial pig farms.
Porcine Health Manag
December 2024
Pig Development Department, Animal and Grassland Research and Innovation Centre, Teagasc Moorepark, P61C996, Fermoy, Co. Cork, Ireland.
Background: Oral fluid contains analytes that may be reflective of health and welfare in pig herds. Additionally, oral fluid collection is a more convenient and cost-effective option when compared to blood sampling, increasing the potential of oral fluid as a non-invasive alternative tool. While a growing number of biomarkers can be measured in porcine oral fluid, the use of these analytes to compare commercial herds in veterinary practice is still limited.
View Article and Find Full Text PDFMortality prediction of inpatients with NSTEMI in a premier hospital in China based on stacking model.
PLoS One
December 2024
Department of Cardiology, The People's Hospital of China Medical University, The People's Hospital of Liaoning Province, Shenyang, China.
Background: Acute myocardial infarction (AMI) remains a leading cause of hospitalization and death in China. Accurate mortality prediction of inpatient is crucial for clinical decision-making of non-ST-segment elevation myocardial infarction (NSTEMI) patients.
Methods: In this study, a total of 3061 patients between January 1, 2017 and December 31, 2022 diagnosed with NSTEMI were enrolled in this study.
Plasma microRNA signatures predict prognosis in canine osteosarcoma patients.
PLoS One
December 2024
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
Appendicular central osteosarcoma (OSA) is a common and highly aggressive tumour in dogs. Metastatic disease to the lungs is common and even with chemotherapy the prognosis is generally poor. However, few cases survive well beyond reported median survival times.
View Article and Find Full Text PDFPersonalized multifactorial risk assessment in neoadjuvant-treated breast carcinoma.
Breast Cancer Res Treat
December 2024
Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10/MedD5A, 20500, Turku, Finland.
Article Synopsis
- The study aims to improve predictions of disease outcomes for breast cancer patients undergoing neoadjuvant treatment (NAT) by analyzing clinical and histopathological data.
- Researchers evaluated a cohort of 257 Finnish breast cancer patients over 13 years, identifying significant prognostic factors and previously overlooked histological features that correlate with treatment response and survival.
- The findings suggest the importance of re-assessing biomarkers post-treatment and developing personalized surveillance and treatment strategies based on comprehensive evaluations of patient data and risk factors.
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