Objective: This study aims to assess the remineralization effect of casein phosphopeptide (CPP)-amorphous calcium phosphate (ACP) on enamel demineralization by performing system review of randomized controlled trials (RCT) involving the treatment of enamel demineralization with CPP-ACP.
Methods: The study was developed based on the
Cochrane handbook for systematic reviews of interventions (Version 5.1.0) and included the following: search strategy, selection criteria, data extraction, and risk of bias assessment. We searched electronic databases such as PubMed, Embase, Cochrane Library, CNKI, Wanfang and VIP up to September 2016. RCT of treating enamel demineralization with CPP-ACP were included. Data extraction and domain-based risk of bias assessment were independently performed by two reviewers.
Results: Twelve RCTs were included. Because of the difference of experimental design and evaluation standards, the quantitative analysis can not be carried out.
Conclusions: There is no strong evidence that CPP-ACP is superior to conventional fluoride formulations in enamel remineralization. However, due to the limitations of sample size, follow-up time and study design, more high quality and large-sample RCT are needed to further verify the evidence.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7041152 | PMC |
| http://dx.doi.org/10.7518/hxkq.2017.06.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of different protocols in preventing demineralization in irradiated human enamel, in vitro study.
BMC Oral Health
January 2025
Department of Operative Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Background: This in vitro study evaluated the efficacy of professional and home-use fluoride regimens for protecting irradiated enamel, undergoing pH cycling resembling xerostomia.
Methods: Sixty human premolar teeth were irradiated with a total dose of 70 Gy and subsequently sectioned into 3 × 3 cm enamel slabs. These slabs were randomly distributed into five groups (n = 12 per group): professional-use groups received fluoride varnish either weekly (FV1) or biweekly (FV2); home-use groups applied 5000 ppm (FT5) or 1450 ppm (FT) fluoride toothpaste; and a control group (control) received no treatment.
Study the effect of ATCC 14917 for caries prevention and anti-obesity.
Front Nutr
December 2024
Department of Pedodontics, Affiliated Stomatology Hospital of Jinzhou Medical University, Jinzhou, China.
Introduction: A complicated scenario where "multiple disease threats coexist and multiple health influencing factors are intertwined" is demonstrated by the fact that dental caries, obesity myopia and scoliosis have emerged as global public health issues. The problem of diseases co-existing in living things can be resolved by using probiotics. , has gained attention recently due to its probiotic properties, useful traits, and potential medical applications.
View Article and Find Full Text PDFBiomimetic and protective effects of bioactive toothpastes on eroded enamel surfaces.
Braz Oral Res
January 2025
Universidade Federal da Paraíba - UFPB, Health Science Center Department of Clinical and Community Dentistry, João Pessoa, PB, Brazil.
This study aimed to evaluate the effectiveness of bioactive toothpastes in remineralizing eroded enamel surfaces in vitro. Bovine enamel blocks (n = 48) were obtained and classified into untreated, demineralized, and treated areas. Specimens were randomly classified into six groups (n = 8 each): fluoride-free toothpaste (NCT), Colgate Total 12 (PCT), Sensodyne Repair and Protect (SRP), Sensodyne Pronamel (SPE), Regenerador + Sensitive (RGS), and RGS/calcium booster (RCB).
View Article and Find Full Text PDFAssessment of Change in Enamel Color and Surface Hardness Following the Use of ICON Resin Infiltration and Remineralizing Agent: An In Vitro Study.
Materials (Basel)
December 2024
Independent Researcher, P.O. Box 60169-38, Riyadh 11545, Saudi Arabia.
This study aimed to evaluate the change in enamel color and surface micro-hardness following the use of resin-infiltration concept material (ICON) and casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) remineralizing agent. Fifty-four extracted human third molars were collected and randomly divided into three groups: group A: control with no surface treatment; group B: treated using ICON; and group C: treated using CPP-ACFP. The change in color and micro-hardness of the enamel surface were measured using spectrophotometer and Vickers hardness number, respectively.
View Article and Find Full Text PDFThe application of deep learning in early enamel demineralization detection.
PeerJ
January 2025
State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Objective: The study aims to develop a diagnostic model using intraoral photographs to accurately detect and classify early detection of enamel demineralization on tooth surfaces.
Methods: A retrospective analysis was conducted with 208 patients aged 14 to 44. A total of 624 high-quality digital images captured under standardized conditions were used to construct a deep learning model based on the Mask region-based convolutional neural network (Mask R-CNN).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!