AI Article Synopsis
- Treatment of refractory unresectable cutaneous squamous cell carcinoma poses significant challenges in head and neck oncology, often leading to poor outcomes.
- Previous case reports indicate that off-label use of pembrolizumab, an immune checkpoint inhibitor, may be effective in these severe cases, especially when there's a high mutational burden.
- This study discusses a patient with advanced unresectable cutaneous squamous cell carcinoma who experienced a complete response to off-label pembrolizumab therapy, despite the tumor invading critical areas like the orbit and cavernous sinus.
Article Abstract
Treatment of refractory, unresectable cutaneous squamous cell carcinoma presents a great challenge in head and neck oncology with poor prognosis. Prior case reports have shown off-label pembrolizumab, a programed cell death receptor antagonist, can be effective in unresectable cutaneous squamous cell carcinoma. Furthermore, prior reports have suggested enhanced efficacy when high mutational burden is present. In this study we present a severe case of unresectable cutaneous squamous cell carcinoma invading the orbit and cavernous sinus with documented tumor mutation. The patient had a complete response to palliative, off-label pembrolizumab therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766284 | PMC |
| http://dx.doi.org/10.1016/j.clsc.2016.11.001 | DOI Listing |
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