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Free thyroxine and TSH interact with secreted protein acidic and rich in cysteine-like 1 in ischemic stroke. | LitMetric

AI Article Synopsis

  • The study investigates the relationship between thyroid hormones and SC1 protein levels in patients who have experienced an ischemic stroke, noting that the role of the thyroid gland in stroke pathology is not fully understood.
  • Results showed significantly higher SC1 levels in stroke patients compared to control subjects, as well as elevated free thyroxine (fT4) levels and lower thyroid-stimulating hormone (TSH) levels in stroke patients.
  • Analysis revealed a positive correlation between SC1 and fT4 and a negative correlation between SC1 and TSH in stroke patients, confirming a link between thyroid hormones and extracellular matrix proteins.

Article Abstract

The role of the thyroid gland in ischemic stroke pathology is not well understood. As thyroid hormones modulate the extracellular matrix, we explored the possible link between them and secreted protein acidic and rich in cysteine like 1 (SC1) - one of the extracellular matrix molecules. In the 81 patients with acute ischemic stroke, serum SC1 levels were much higher compared with 30 control subjects: 4.47 vs 2.43ng/mL (p<0.001). Serum levels of free thyroxine (fT4) were higher in stroke subjects compared to those of controls (p=0.03). In stroke patients, TSH concentration was lower than in the control group (p=0.03). SC1 levels positively correlated with fT4 levels (p=0.02) and negatively with TSH (p=0.03) in stroke patients. Our results confirmed the association between thyroid hormones and SC1 - extracellular matrix protein.

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Source
http://dx.doi.org/10.1016/j.pjnns.2018.01.001DOI Listing

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