Forest musk deer (Moschus berezovskii; FMD) are both economically valuable and highly endangered. A problem for FMD captive breeding programs has been the susceptibility of FMD to abscesses. To investigate the mechanisms of abscess development in FMD, the blood transcriptomes of three purulent and three healthy individuals were generated. A total of ~39.68 Gb bases were generated using Illumina HiSeq 4000 sequencing technology and 77,752 unigenes were identified after assembling. All the unigenes were annotated, with 63,531 (81.71%) mapping to at least one database. Based on these functional annotations, 45,798 coding sequences (CDS) were detected, along with 12,697 simple sequence repeats (SSRs) and 65,536 single nucleotide polymorphisms (SNPs). A total of 113 unigenes were found to be differentially expressed between healthy and purulent individuals. Functional annotation indicated that most of these differentially expressed genes were involved in the regulation of immune system processes, particularly those associated with parasitic and bacterial infection pathways.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766596 | PMC |
| http://dx.doi.org/10.1038/s41598-017-18534-0 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Preliminary exploration of the musk biosynthetic mechanism by transcriptomic sequencing in muskrats.
Sci Rep
November 2024
Bio-Resource Research and Utilization Joint Key Laboratory of Sichuan and Chongqing, Chongqing Institute of Medicinal Plant Cultivation, Chongqing, China.
Musk, secreted by adult male forest musk deer, is a kind of precious Chinese traditional medicine for treating cardiovascular, cerebrovascular and neurogenic diseases. However, a lack of knowledge on musk biosynthetic mechanism and limited musk deer population have seriously hindered the development of the musk industry. Fortunately, given that muskrat musk has similar constituents and pharmacological action with deer musk, muskrat is an ideal model animal for exploring musk biosynthetic mechanism.
View Article and Find Full Text PDFFurazolidone reduces the pathogenesis of and co-infection in a mouse model.
Heliyon
October 2024
Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, School of Pharmacy, Chengdu University, Chengdu, 610106, China.
The prevalence of abscess disease significantly limits the population expansion of captive forest musk deer, which is an endangered species protected by the legislation of China. Our prior work had demonstrated that and are two important microorganisms in causing the abscess disease of forest musk deer, and furazolidone could inhibit the growth and virulence of the pathogens . In this study, the protection activity of furazolidone was evaluated by using mouse models chronically infected with and .
View Article and Find Full Text PDFMonocrotaline-mediated autophagy via inhibiting PI3K/AKT/mTOR pathway induces apoptosis in rat hepatocytes.
Front Pharmacol
October 2024
Shaanxi Engineering Research Center of the Prevention and Control for Animal Disease, Yangling Vocational and Technical College, Yangling, Shaanxi, China.
Monocrotaline (MCT), a major pyrrolizidine alkaloid, is well-known for its high liver toxicity. Dysregulation of autophagy induced apoptosis can lead to various liver diseases, including those induced by chemical compounds. Therefore, we aim to explore whether autophagy might serve as a potential strategy for addressing liver apoptosis caused by MCT.
View Article and Find Full Text PDFEfficacy and safety of low-dose rituximab in the treatment of myasthenia gravis: a systemic review and meta-analysis.
Front Neurol
September 2024
Department of Neurology, Changzhi People's Hospital, Changzhi, China.
Article Synopsis
- Rituximab (RTX) is a monoclonal antibody increasingly used to treat myasthenia gravis (MG), with studies investigating the effectiveness of low doses, although its benefits continue to be debated.* -
- A systematic review and meta-analysis of 17 studies with 292 patients showed that 91% experienced improved clinical status after RTX treatment, and their Quantitative Myasthenia Gravis (QMG) scores significantly decreased.* -
- In subgroups, 90% of patients with acetylcholine receptor antibody-positive MG and 97% of those with muscle-specific kinase antibody-positive MG reported clinical improvements, highlighting RTX's potential efficacy in treating different MG types.*
Single-nucleus multiomics unravels the genetic mechanisms underlying musk secretion in Chinese forest musk deer (Moschus berezovskii).
Int J Biol Macromol
November 2024
College of Animal Science and Technology, Northwest A&F University, Yangling 712100, Shaanxi, China. Electronic address:
Musk secreted by the musk glands in male forest musk deer (FMD; Moschus berezovskii) is highly valued for its pharmaceutical and perfumery applications. However, the regulatory mechanisms underlying musk secretion are not well understood. This study aimed to investigate the genes and transcription factors involved in musk secretion across different periods and ages.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!