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Yield of family screening in patients with isolated bicuspid aortic valve in a general hospital. | LitMetric

AI Article Synopsis

  • The study aimed to find out how common it is to have unknown bicuspid aortic valve (BAV) or aortic dilation in first-degree relatives (FDR) of patients with isolated BAV.
  • Researchers screened 134 FDR of 54 patients with isolated BAV, discovering that 6% had BAV and 7.5% had aortic dilation, indicating a notable prevalence among relatives.
  • The findings suggest that screening FDR in a general hospital setting can reveal a significant number of new cases, with 13% of screened individuals either having BAV or aortic dilation.

Article Abstract

Aim: To determine the prevalence of unidentified bicuspid aortic valve (BAV) or aortic dilatation (>40mm) in first degree relatives (FDR) of patients with isolated BAV in a general hospital.

Methods And Results: Patients with isolated BAV received information advising cardiac screening of their FDR. Referred and screened were 134 FDR of 54 adult index patients with isolated BAV (median 2 per index patient). FDR's mean age was 49years (range 16-83years) and 41% were male. They comprised 5 parents (3.7%), 52 siblings (39%) and 77 offspring (57%). Among these FDR, the prevalence of BAV was 6.0% (8 patients). In FDR without BAV, 10 (7.5%) had aortic dilatation. 'Familial BAV' was present in 9/54 families (17%).

Conclusion: In a general hospital, screening of FDR of patients with isolated BAV resulted in a substantial yield of 13% new cases with BAV or aortic dilatation without BAV.

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Source
http://dx.doi.org/10.1016/j.ijcard.2017.12.046DOI Listing

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