The Flow Cytometry is the principal method used to measure platelet-derived microparticles (PDMPs), by fluorescent properties analysis. PDMPs (0.1-1.0 μm) are abundant in circulation, accounting for approximately 90% of the microparticles and are associated with Cardiovascular Disease, the leading cause of death in the world.
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Complex Pattern of Platelet Activation/Reactivity After SARS-CoV-2 Infection.
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COVID-19 and post-COVID (long COVID) are associated with thromboembolic complications; however, it is still not clear whether platelets play a leading role in this phenomenon. The platelet hyperreactivity could result from the direct interaction between platelets and viral elements or the response to inflammatory and prothrombotic factors released from blood and vessel cells following infection. The existing literature does not provide clear-cut answers, as the results determining platelet status vary according to methodology.
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Nat Biotechnol
December 2024
Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI, USA.
Clinical application of chimeric molecules for targeted protein degradation has been limited by unfavorable drug-like properties and biosafety concerns arising from nonspecific biodistribution after systemic administration. Here we develop a method to engineer platelets for degradation of either intracellular or extracellular proteins of interest (POIs) in vivo by covalently labeling heat shock protein 90 (HSP90) in platelets with a POI ligand. The degrader platelets (DePLTs) target wound areas and undergo activation.
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First Department of Internal Medicine, Kansai Medical University, Hirakata, Japan.
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Thromb Res
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Hematology Unit, First Department of Internal Medicine, Laikon General Hospital, National & Kapodistrian University of Athens, Athens, Greece.
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Nanoscale
December 2024
School of Biotechnology and Key Laboratory of Carbohydrate Chemistry and Biotechnology of Ministry of Education, Jiangnan University, Wuxi 214122, China.
Advances in molecular biology have enabled the identification of numerous cancer biomarkers, offering the potential to improve the diagnosis and prognosis of cancer. In non-small cell lung cancer (NSCLC), the role of platelet-derived microvesicles (PMVs) in cancer progression has received limited attention. While previous studies have focused on the increase of extracellular vesicles in plasma and their interaction with cancer, the expression of microRNAs (miRNAs) delivered through PMVs following platelet activation has remained largely unexplored.
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