AI Article Synopsis
- The study monitored lymphocyte suppressor cell function in ten patients with systemic lupus erythematosus (SLE) over nine months.
- The method involved using ConA to activate suppressor T cells that inhibit immunoglobulin (IgG) synthesis in PWM-stimulated lymphocytes.
- Findings revealed significant IgG suppression impairment in nine out of ten SLE patients, with no correlation to disease activity or treatment protocols.
Article Abstract
In ten patients with systemic lupus erythematosus lymphocyte suppressor cell function was repeatedly monitored over a period of nine months. The method used is based on the finding that in vitro addition of ConA to PWM-stimulated lymphocytes activates suppressor T cells which in turn inhibit immunoglobulin synthesis. Nine of ten SLE patients exhibited significant impairment of IgG suppression but no correlation was found between the outcome of the IgG suppressor cell assay and disease activity or the treatment protocol applied.
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