For the last decade melatonin has attracted attention as a neuroregulator in pathogenesis of obesity and metabolic syndrome. The aim of our study is to evaluate the characteristics of metabolic secretion in obese women of reproductive age. The study was conducted on the total number of 120 women. Eighty women with obesity formed the case group, and forty healthy women - the control group. Carbohydrate metabolism, lipid profile and serum levels of melatonin were evaluated in all study subjects. According to the results, 61.3% of the total study population had insulin resistance and 60% had dyslipidemia. Melatonin hypersecretion, with the mean level of melatonin 129.4±124.9, was observed in the case group. The mean level of melatonin in the control group was 107.5±10.9, which was 17% less than in the case group. Melatonin secretion was in significant correlation with patients' age (P=0.022), family history of myocardial infarction (P=0.030), excess carbohydrate intake (P=0.051) and enlarged ovaries (P=0.050). Our results confirm the relationship between obesity, metabolic abnormalities (insulin resistance, dyslipidemia) and melatonin hypersecretion in women of reproductive age.
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