AI Article Synopsis
- - The study aims to determine the relationship between pretransplant neutrophil-lymphocyte ratio (NLR) and patient prognosis in liver transplantation for hepatocellular cancer (HCC) through a meta-analysis of 13 research studies.
- - Data from 1,936 patients revealed that a higher pretransplant NLR is significantly linked to better overall survival, recurrence-free survival, and disease-free survival after liver transplantation.
- - The findings suggest that elevated pretransplant NLR could serve as a valuable prognostic indicator for patients undergoing liver transplantation for HCC, indicating its potential clinical importance.
Article Abstract
Aim: Recently, many reports showed that the pretransplant neutrophil-lymphocyte ratio (NLR) may be correlated with the prognosis of patients undergoing liver transplantation (LT) for hepatocellular cancer (HCC). However, their results still remained controversial. Thus we performed a meta-analysis of 13 studies to estimate the prognostic value of pretransplant NLR.
Methods: Databases including PubMed, Embase, Cochrane Library and Web of Science were searched to September 2017. Hazard ratio (HR) or odds ratio (OR) with its 95% CI was used to evaluate the association between elevated NLR and the prognosis or clinical features of liver cancer patients.
Results: A total of 13 studies including 1936 patients were included in this meta-analysis. Elevated pretransplant NLR had a close association with the overall survival (HR: 2.22; 95% CI: 1.34-3.68), recurrence-free survival (HR: 3.77; 95% CI: 2.01-7.06) and disease-free survival (HR: 2.51; 95% CI: 1.22-5.15) of patients undergoing LT for HCC, respectively. In addition, elevated NLR was associated with the presence of vascular invasion (OR: 2.39; 95% CI: 1.20-4.77) and Milan criteria (OR: 0.26; 95% CI: 0.17-0.40).
Conclusion: The results of this meta-analysis showed that elevated pretransplant NLR may be used as a new prognostic predictor after LT for HCC.
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| http://dx.doi.org/10.2217/bmm-2017-0307 | DOI Listing |
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