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| http://dx.doi.org/10.1002/ajh.25036 | DOI Listing |
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Orosomucoid 1 interacts with S100A12 and activates ERK signalling to expedite the advancement of bladder cancer.
Cell Adh Migr
December 2025
Department of Urology, Chongqing General Hospital, Chongqing University, Chongqing, China.
The research endeavors to expound the role of ORM1 in bladder cancer (BCa) and the implied response mechanism. RT-qPCR and Western blotting examined ORM1 and S100A12 expression. Functional experiments assessed the cellular phenotypes.
View Article and Find Full Text PDFA study of size-selective renal elimination using a novel human model.
Scand J Clin Lab Invest
April 2024
Department of Cardiothoracic Surgery, Skåne University Hospital, Lund University, Lund, Sweden.
Article Synopsis
- A new study explored how the kidneys eliminate molecules of different sizes using a human model during Transcatheter Aortic Valve Implantation (TAVI) on 45 patients.
- * Researchers measured the renal elimination ratio (RER) of various molecules, finding that smaller molecules like creatinine had a higher RER compared to larger ones like troponin-T, revealing a threshold for elimination between 36 and 44 kDa.
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Background: Focal segmental glomerulosclerosis (FSGS) is a primary podocytopathy characterized by primary podocyte detection and high proteinuria. The search for biomarkers and factors associated with the progression of this disease is an important task nowdays.
Aim: To assess the proteomic profile of urine in patients with FSGS and to isolate urinary biomarkers of podocytopathies.
Urinary orosomucoid and retinol binding protein levels as early diagnostic markers for diabetic kidney Disease.
BMC Nephrol
December 2023
College of Medicine, Henan Polytechnic University, Jiaozuo, China.
Background: Diabetic kidney disease (DKD) is the most common microvascular complication of diabetes, which has been a major cause of end-stage renal failure. Diagnosing diabetic kidney disease is important to prevent long-term kidney damage and determine the prognosis of patients with diabetes. In this study, we investigated the clinical significance of combined detection of urine orosomucoid and retinol-binding protein for early diagnosis of diabetic kidney disease.
View Article and Find Full Text PDFMeasurement of Urinary Gc-Globulin by a Fluorescence ELISA Technique: Method Validation and Clinical Evaluation in Septic Patients-A Pilot Study.
Molecules
September 2023
Department of Anesthesiology and Intensive Therapy, Medical School, University of Pécs, 7624 Pécs, Hungary.
A major complication of sepsis is the development of acute kidney injury (AKI). In case of acute tubular damage, Gc-globulin, a known serum sepsis marker is increasingly filtrated into the urine therefore, urinary Gc-globulin (u-Gc) levels may predict septic AKI. We developed and validated a competitive fluorescence ELISA method for u-Gc measurement.
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