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Determination of birth prevalence of sickle cell disease using point of care test HemotypeSC™ at Rundu Hospital, Namibia.
BMC Pediatr
May 2024
Department of Human, Biological and Translational Medical Sciences, School of Medicine, University of Namibia Faculty of Health Sciences & Veterinary Medicine, Windhoek, Namibia.
Background: Sickle cell disease (SCD), a noncommunicable disease, has the greatest burden in sub-Saharan Africa. The majority of children (50-90%) with SCD die before their 5th birthday, with approximately 150,000-300,000 annual SCD child deaths in Africa. In developed countries, newborn screening (NBS) has been shown to improve the survival of children with sickle cell disease, with under5 childhood mortality reduced tenfold due to interventions performed before the development of complications.
View Article and Find Full Text PDFTowards elimination of chronic viral hepatitis in French Polynesia: results from a national population-based survey.
Lancet Reg Health West Pac
April 2024
Laboratory of Research on Emerging Viral Diseases, Institut Louis Malardé, Papeete, Tahiti, French Polynesia.
Article Synopsis
- - This study investigates the prevalence of hepatitis B virus (HBV) in French Polynesia, where HBV infection significantly increases the risk of hepatocellular carcinoma (HCC), especially in the Austral archipelago, known for its high detection rates.
- - Blood samples from nearly 2,000 adults were tested, revealing that 1.0% were carriers of HBV, with higher rates found specifically in certain areas like the Austral and Marquesas archipelagos. Factors such as location, age, and education level influenced HBV carriage.
- - Although French Polynesia generally shows low HBV endemicity and low risk for hepatitis C and delta infections, the findings highlight a need for improved detection and prevention efforts, especially
Impact of anti-HDV reflex testing at HBs antigen positive discovery in a single center France: Support for primary HDV screening in France.
J Clin Virol
April 2024
Unité Mixte de Recherche (UMR) S1109 Labex Transplantex, Institut National de la Santé et de la Recherche Médicale (Inserm) Fédération de Médecine Translationnelle, Strasbourg University, Strasbourg France, Department of Virology, Institut de Virologie, Strasbourg University Hospital, 3 rue Koeberlé, Strasbourg F67000, France. Electronic address:
Article Synopsis
- Hepatitis Delta virus (HDV) significantly contributes to liver-related health issues in patients with HBV, prompting France to enhance testing for anti-HDV antibodies in HBsAg-positive individuals since January 2022.
- A study comparing six years of serology data showed a more than 2-fold increase in HDV diagnoses among HBsAg carriers and a notable rise in anti-HDV positive rates from 6.8% to 10.3% overall.
- The improved testing strategy has allowed for earlier identification of HBV-HDV co-infected patients, enabling timely referrals to specialists and potential treatment with bulevirtide, signaling promising outcomes for patient management.
Influence of the sickle cell trait on Plasmodium falciparum infectivity from naturally infected gametocyte carriers.
BMC Infect Dis
May 2023
Institut de Recherche pour le Développement, MIVEGEC, Univ. Montpellier, CNRS, IRD, 91 Avenue Agropolis, BP 64501, 34394, Montpellier, France.
Background: Sickle cell trait (SCT) refers to the carriage of one abnormal copy of the β-globin gene, the HbS allele. SCT offers protection against malaria, controlling parasite density and preventing progression to symptomatic malaria. However, it remains unclear whether SCT also affects transmission stages and mosquito infection parameters.
View Article and Find Full Text PDF[Prevalence Of Antigen HBs Carriage In A Population Of Candidates For The National Gendarmerie Recruitment In Abidjan].
Mali Med
January 2023
Service des Maladies Infectieuses et Tropicales, CHU de Bouaké.
Objective: The aim of this study was to determine the prevalence of HBsAg carriage in candidates for gendarmerie recruitment.
Methods: This was a prospective cross-sectional study conducted from April 7, 2010 to September 12, 2010 at the Abidjan military hospital. It involved candidates for the national gendarmerie competitive examination who agreed to take part in the study.
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