AI Article Synopsis
- - Sepsis is a major cause of death in intensive care units, characterized by uncontrolled inflammation and immune system failure, leading to poor patient outcomes with limited specific treatments.
- - Autophagy, a cellular survival mechanism, shows promise in preserving immune function and reducing organ failure, which could enhance survival rates in septic conditions.
- - Various drugs and strategies that promote autophagy have been identified as beneficial in sepsis, suggesting that targeting autophagy could help counteract the immune suppression seen in septic patients.
Article Abstract
Sepsis remains the leading cause of mortality in intensive care units and an intractable condition due to uncontrolled inflammation together with immune suppression. Dysfunction of immune cells is considered as a major cause for poor outcome of septic patients but with little specific treatments. Currently, autophagy that is recognized as an important self-protective mechanism for cellular survival exhibits great potential for maintaining immune homeostasis and alleviating multiple organ failure, which further improves survival of septic animals. The protective effect of autophagy on immune cells covers both innate and adaptive immune responses and refers to various cellular receptors and intracellular signaling. Multiple drugs and measures are reportedly beneficial for septic challenge by inducing autophagy process. Therefore, autophagy might be an effective target for reversing immunosuppression compromised by sepsis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5741675 | PMC |
| http://dx.doi.org/10.3389/fimmu.2017.01832 | DOI Listing |
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