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Orexin knockout mice exhibit impaired spatial working memory. | LitMetric

Orexin knockout mice exhibit impaired spatial working memory.

Neurosci Lett

Department of Physiology, Collaborative Innovation Center for Brain Science, Third Military Medical University, Chongqing, 400038, PR China. Electronic address:

Published: March 2018

AI Article Synopsis

  • Orexins are important for maintaining arousal and regulating cognitive functions, including learning and memory.
  • A study assessed working memory in mice lacking orexin by using a T-maze task, revealing that these orexin knockout (KO) mice performed worse over time compared to wild-type controls.
  • While the orexin KO mice did not show differences in overall movement, they explored fewer displaced objects, suggesting that orexins significantly impact spatial working memory.

Article Abstract

Orexins play a crucial role in the maintenance of arousal and are involved in the modulation of diverse physiological process, including cognitive function. Recent data have suggested that orexins are involved in learning and memory processes. The purpose of this study was to assess the effects of orexin deficiency on working memory. A delayed non-matching-to-place T-maze task was used to evaluate spatial working memory in mice lacking orexin prepro-peptide (orexin knockout; KO) and wild-type controls. We demonstrated that the number of correct choices in the orexin KO mice became lower than that of the controls over training. In an object exploration task, the controls explored the displaced object more than the mutants did, whereas this difference was not observed for the nondisplaced objects in either group. The orexin KO mice showed locomotor activity comparable to the control mice in terms of total distance traveled across training in both the object exploration task and the open field test. These findings indicate that the orexin system plays an important role in working memory of spatial cues.

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Source
http://dx.doi.org/10.1016/j.neulet.2018.01.013DOI Listing

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