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Clinical Efficacy and Safety of Teriparatide Versus Alendronate in Postmenopausal Osteoporosis: A Systematic Review of Randomized Controlled Trials.
Cureus
November 2024
Pharmacology, Sir Seewoosagur Ramgoolam Medical College, Belle Rive, MUS.
Alendronate, a second-generation bisphosphonate, remains the first-line therapeutic option for postmenopausal osteoporosis. It acts on the bone resorbing osteoclasts causing their apoptosis. This is achieved by producing toxic adenosine triphosphate (ATP) analogues and interfering with the mevalonate pathway.
View Article and Find Full Text PDFChanges in Rehmanniae Radix processing and their impact on ovarian hypofunction: potential mechanisms of action.
Front Pharmacol
July 2024
Department of Gynecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Objective: This study evaluates the research developments concerning Rehmanniae Radix in ovarian hypofunction diseases. It explores the processing methods of Rehmanniae Radix, the variations in its compounds before and after processing, the mechanism of Rehmanniae Radix and its active compounds in improving ovarian function, and the advancements in clinical applications of traditional Chinese medicine (TCM) compound that include Rehmanniae Radix.
Methods: Comprehensive literature search was conducted using databases such as China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database, National Science and Technology Library, the Pharmacopoeia of the People's Republic of China, Pubmed, and the Web of Science Database.
Systematic Review and Meta-Analysis of the Effect of Osteoporosis on Fusion Rates and Complications Following Surgery for Degenerative Cervical Spine Pathology.
Int J Spine Surg
July 2024
Department of Orthopaedic Surgery, Keck School of Medicine at The University of Southern California, Los Angeles, CA, USA.
Article Synopsis
- The growing elderly population is facing challenges due to osteoporosis, which affects bone strength and can lead to complications in cervical spine surgeries.
- A systematic review evaluated postoperative outcomes for patients with cervical degenerative disease or deformity, focusing on factors like bone density and complication rates.
- Results indicated that lower bone mineral density in osteoporotic patients is linked to higher rates of equipment failure and increased risk of complications, although the impact on other surgical outcomes is mixed.
What is known about osteoporosis research in Latin America?: A bibliometric analysis of three decades.
Medicine (Baltimore)
December 2023
Facultad de Ciencias de la Salud, Escuela de Medicina, Universidad César Vallejo, Trujillo, Peru.
Identifying the gaps in scientific production in a topic allows directing research in order to make better public investment decisions. Bibliometric data on osteoporosis in Latin America are very limited and unclear and, given the impact of this disease in this region, it is relevant to analyze the latest trends in the subject. The study approach was quantitative, observational-descriptive, cross-sectional.
View Article and Find Full Text PDFThe aetiology of atypical bone health in individuals with Down syndrome.
Arch Osteoporos
November 2023
School of Health and Behavioural Sciences, University of the Sunshine Coast, Brisbane, QLD, Australia.
Purpose: Trisomy 21 (T21), more commonly known as Down syndrome (DS) is a genetic condition where every cell in the body has an additional copy of chromosome 21. Despite improvements in our management of DS-associated health risks, we still do not understand how T21 impacts human bone health. This is a critical area of research owing to increased life expectancy of people with DS, and the predisposition of individuals with DS to early-onset osteoporosis and osteopenia.
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