[This corrects the article DOI: 10.1371/journal.pone.0186248.].
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J Mammary Gland Biol Neoplasia
January 2025
Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Fluorescent biosensors offer a powerful tool for tracking and quantifying protein activity in living systems with high temporospatial resolution. However, the expression of genetically encoded fluorescent proteins can interfere with endogenous signaling pathways, potentially leading to developmental and physiological abnormalities. The EKAREV-NLS mouse model, which carries a FRET-based biosensor for monitoring extracellular signal-regulated kinase (ERK) activity, has been widely utilized both in vivo and in vitro across various cell types and organs.
View Article and Find Full Text PDFEur Arch Otorhinolaryngol
January 2025
Vrije Universiteit Brussel, Brussels Health Centre, Brussels, Belgium.
Purpose: Cochlear implants (CI) are the most successful bioprosthesis in medicine probably due to the tonotopic anatomy of the auditory pathway and of course the brain plasticity. Correct placement of the CI arrays, respecting the inner ear anatomy are therefore important. The ideal trajectory to insert a cochlear implant array is defined by an entrance through the round window membrane and continues as long as possible parallel to the basal turn of the cochlea.
View Article and Find Full Text PDFGait Posture
January 2025
Department of Orthopaedics, BC Children's Hospital, 4500 Oak St, Vancouver, BC V6H 3N1, Canada; The Motion Lab, Sunny Hill Health Centre, 4480 Oak St, Vancouver, BC V6H 3N1, Canada; University of British Columbia, Faculty of Medicine, Department of Orthopaedics, 317 - 2194 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.
Background: Split tendon transfer of the posterior tibialis (SPOTT) is a surgical procedure in which the split posterior tibialis tendon is transferred posterior to the fibula (PO) with insertion on the peroneus brevis tendon to rebalance the forces across the hindfoot. Routing of the split tendon through the interosseous membrane (IO) is a variation with the potential benefit of augmenting ankle dorsiflexion in swing.
Research Question: Does IO routing improve ankle dorsiflexion in swing and/or varus in stance compared to PO routing?
Methods: A retrospective chart review was completed to identify forty-two patients who underwent a SPOTT procedure for equinovarus foot deformity.
Prune belly syndrome (PBS), or Eagle-Barrett syndrome, is a rare congenital disorder marked by abdominal wall muscle deficiency, urinary tract anomalies, and cryptorchidism, causing significant abdominal wall laxity and functional impairment. This case report discusses an innovative approach to abdominal wall reconstruction in a 19-year-old male patient with PBS and associated conditions, including chronic renal failure and spina bifida. Previously, he underwent distal ureterectomy and vesicoureteral reimplantation at the age of two years to correct urinary tract dilation and bilateral orchiopexy.
View Article and Find Full Text PDFSpatial skills like block building and puzzle making are associated with later growth in science, technology, engineering, and mathematics learning. How these early spatial experiences-both in concrete and digital platforms-boost children's spatial skills remains a mystery. This study examined how children with low- and high-parental education use corrective feedback in a series of spatial assembly tasks.
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