This paper focuses on the control of rotating helical microrobots inside microchannels. We first use a 50 μm long and 5 μm in diameter helical robot to prove that the proximity of the channel walls create a perpendicular force on the robot. This force makes the robot orbit around the channel center line. We also demonstrate experimentally that this phenomenon simplifies the robot control by guiding it on a channel even if the robot propulsion is not perfectly aligned with the channel direction. We then use numerical simulations, validated by real experimental cases, to show different implications on the microrobot control of this orbiting phenomenon. First, the robot can be centered in 3D inside an in-plane microchannel only by controlling its horizontal direction (yaw angle). This means that a rotating microrobot can be precisely controlled along the center of a microfluidic channel only by using a standard 2D microscopy technology. Second, the robot horizontal (yaw) and vertical (pitch) directions can be controlled to follow a 3D evolving channel only with a 2D feedback. We believe this could lead to simplify imaging systems for the potential in vivo integration of such microrobots.
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http://dx.doi.org/10.1038/s41598-017-18891-w | DOI Listing |
Biomed Microdevices
January 2025
Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, 111 Suwannabhumi Canal Rd, Bang Pla, Bang Phli District, Samut Prakan, 10540, Thailand.
Microfluidic chips often face challenges related to the formation and accumulation of air bubbles, which can hinder their performance. This study investigated a bubble trapping mechanism integrated into microfluidic chip to address this issue. Microfluidic chip design includes a high shear stress section of fluid flow that can generate up to 2.
View Article and Find Full Text PDFSmall Methods
November 2024
Department of Mechanical Engineering, American University of Sharjah, Sharjah, UAE.
The purpose of this study is to characterize the dynamic response of fluid flow in microchannels, which can show significant delay times before reaching steady flow conditions. Two main sources of these delays are numerically and experimentally investigated, the hydraulic compliance which originates from the flexibility of the system components (microchannel, tubing, syringe, etc.), and the compressibility of the liquid dead volume in the setup, also known as the "bottleneck effect".
View Article and Find Full Text PDFBiomicrofluidics
December 2024
Division of Radiation Biomedical Research, Korea Institute of Radiological & Medical Sciences, 75 Nowon-ro, Nowon-gu, Seoul 01812, South Korea.
Considerable attention has been given to elasto-inertial microfluidics, which are widely applied for the focusing, sorting, and separation of particles/cells. In this work, we propose a novel yet simple fabrication process for a microchannel with a cruciform section, where elasto-inertial particle focusing is explored in a viscoelastic fluid. SU-8 master molds for polydimethylsiloxane (PDMS) structures were fabricated via standard photolithography, and then plasma bonding, following self-alignment between two PDMS structures, was performed for the formation of a microchannel with a cruciform section.
View Article and Find Full Text PDFAnn Biomed Eng
November 2024
LaBS - Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milano, Italy.
Sensors (Basel)
October 2024
College of Optical and Electronic Technology, China Jiliang University, Hangzhou 310018, China.
A highly sensitive optical fiber gas pressure sensor with temperature monitoring is proposed and demonstrated. It is based on a slightly tapered fiber with an inner micro-cavity forming an in-fiber Mach-Zehnder interferometer (MZI), and a micro-channel is drilled into the lateral wall of the in-fiber micro-cavity using a femtosecond laser to allow gas to flow in. Due to the dependence of the refractive index (RI) of air inside the micro-cavity on its gas pressure and the high RI sensitivity of the MZI, the device is extremely sensitive to gas pressure.
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