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Recent Advances in Strategies to Enhance Photodynamic and Photothermal Therapy Performance of Single-Component Organic Phototherapeutic Agents.
Adv Sci (Weinh)
January 2025
The Department of Medical Imaging, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Xingangzhong Road 466, Guangzhou, 518037, P. R. China.
Photodynamic therapy (PDT) and photothermal therapy (PTT) have emerged as promising treatment options, showcasing immense potential in addressing both oncologic and nononcologic diseases. Single-component organic phototherapeutic agents (SCOPAs) offer advantages compared to inorganic or multicomponent nanomedicine, including better biosafety, lower toxicity, simpler synthesis, and enhanced reproducibility. Nonetheless, how to further improve the therapeutic effectiveness of SCOPAs remains a challenging research area.
View Article and Find Full Text PDFSequential Targeting Chondroitin Sulfate-Bilirubin Nanomedicine Attenuates Osteoarthritis via Reprogramming Lipid Metabolism in M1 Macrophages.
Adv Sci (Weinh)
January 2025
Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
The infiltration and excessive polarization of M1 macrophages contribute to the induction and persistence of low-grade inflammation in joint-related degenerative diseases such as osteoarthritis (OA). The lipid metabolism dysregulation promotes M1 macrophage polarization by coordinating the compensatory pathways of the inflammatory and oxidative stress responses. Here, a self-assembling, licofelone-loaded nanoparticle (termed LCF-CSBN), comprising chondroitin sulfate and bilirubin joined by an ethylenediamine linker, is developed to selectively reprogram lipid metabolism in macrophage activation.
View Article and Find Full Text PDFGenerative Artificial Intelligence: Applications in Scientific Writing and Data Analysis in Wound Healing Research.
Adv Skin Wound Care
January 2025
At the Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, United States, Adrian Chen, BS, Aleksandra Qilleri, BS, and Timothy Foster, BS, are Medical Students. Amit S. Rao, MD, is Project Manager, Department of Surgery, Wound Care Division, Northwell Wound Healing Center and Hyperbarics, Northwell Health, Hempstead. Sandeep Gopalakrishnan, PhD, MAPWCA, is Associate Professor and Director, Wound Healing and Tissue Repair Analytics Laboratory, School of Nursing, College of Health Professions, University of Wisconsin-Milwaukee. Jeffrey Niezgoda, MD, MAPWCA, is Founder and President Emeritus, AZH Wound Care and Hyperbaric Oxygen Therapy Center, Milwaukee, and President and Chief Medical Officer, WebCME, Greendale, Wisconsin. Alisha Oropallo, MD, is Professor of Surgery, Donald and Barbara Zucker School of Medicine and The Feinstein Institutes for Medical Research, Manhasset New York; Director, Comprehensive Wound Healing Center, Northwell Health; and Program Director, Wound and Burn Fellowship program, Northwell Health.
Generative artificial intelligence (AI) models are a new technological development with vast research use cases among medical subspecialties. These powerful large language models offer a wide range of possibilities in wound care, from personalized patient support to optimized treatment plans and improved scientific writing. They can also assist in efficiently navigating the literature and selecting and summarizing articles, enabling researchers to focus on impactful studies relevant to wound care management and enhancing response quality through prompt-learning iterations.
View Article and Find Full Text PDFConvertible Hydrogel Injection Sequentially Regulates Diabetic Periodontitis.
ACS Biomater Sci Eng
January 2025
Chongqing Key Laboratory of Reproductive Health and Digital Medicine, Department of Laboratory Medicine, Chongqing General Hospital, School of Medicine, Chongqing University, Chongqing 401147, China.
Diabetes exacerbates periodontitis by overexpressing reactive oxygen species (ROS), which leads to periodontal bone resorption. Consequently, it is imperative to relieve inflammation and promote alveolar bone regeneration comprehensively for the development of diabetic periodontal treatment strategies. Furthermore, an orderly treatment to avoid interference between these two processes can achieve the optimal therapeutic effect.
View Article and Find Full Text PDFMove Better, Live Better: A novel supervised combined training for peripheral arterial disease: A quasi-experimental approach.
Am J Phys Med Rehabil
January 2025
"i+HeALTH" Strategic Research Group, Department of Health Sciences, Miguel de Cervantes European University (UEMC), Valladolid, Spain.
Objective: This study aimed to analyze the effect of a novel supervised exercise therapy (SET) program based on intermittent treadmill walking and circuit-based moderate-intensity functional training (MIFT) on walking performance and HRQoL in PAD patients.
Design: All participants underwent a 12-week SET that involved 15 to 30 minutes of treadmill walking followed by a 15-minute moderate-intensity functional training (MIFT) continued by 12-week of follow-up. Maximum walking distance (MWD), pain-free walking distance (PFWD), gait speed and estimated peak oxygen uptake (peak VO2) were calculated through the 6-minute walk test (6-MWT) and HRQoL through the Short Form-36 (SF-36) and the Vascular Quality of Life Questionnaire-6 (VascuQol-6).
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