Introduction: Both heroin use and depression are significant health problems. Methadone maintenance treatment (MMT) can be of great benefit to heroin users. However, changes in the level of depression in heroin users during MMT are not clear. Gender and age are also important factors in the development of depression, and whether gender and age moderate changes in depression in heroin users during MMT warrants further study. This study aimed to explore: (1) the trajectory of depression in opioid users during MMT and (2) the moderating effects of gender and age on the trajectory of depression in opioid users receiving MMT.
Method: A total of 294 intravenous heroin users were recruited into this 9-month observational study. The level of depression was measured at the intake interview and at follow-up interviews every 3 months. A latent growth model was used to analyze the trajectory of the level of depression among the participants.
Results: Depression improved rapidly during the first 3 months of MMT and slowly after the first 3 months in both the female and male heroin users. There was no gender difference in the level of depression at each follow-up point. The level of depression in the female heroin users decreased faster than that in the male heroin users. In addition, the level of depression in the younger heroin users decreased faster than that in the older subjects.
Conclusion: Depression in female and younger heroin users improved more rapidly than in male and older subjects, respectively.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5733537 | PMC |
| http://dx.doi.org/10.3389/fpsyt.2017.00288 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Qualitative findings from North America's first drug compassion club.
PLoS One
December 2024
Department of Medicine, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
In Canada, the ongoing fatal overdose crisis remains driven by the unpredictable potency and content of the illicit drug supply. From August 2022 until October 2023, the Drug User Liberation Front [DULF] operated a drug compassion club [CC], which sells drugs of known composition and purity without medical oversight. The present study is a qualitative evaluation of this project.
View Article and Find Full Text PDFMachine learning analysis of the orbitofrontal cortex transcriptome of human opioid users identifies Shisa7 as a translational target relevant for heroin-seeking leveraging a male rat model.
Biol Psychiatry
December 2024
Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Addiction Institute of Mount Sinai, New York, New York, USA. Electronic address:
Background: Identifying neurobiological targets predictive of the molecular neuropathophysiological signature of human opioid use disorder (OUD) could expedite new treatments. OUD is characterized by dysregulated cognition and goal-directed behavior mediated by the orbitofrontal cortex (OFC), and next-generation sequencing could provide insights regarding novel targets.
Methods: Here, we used machine learning to evaluate human post-mortem OFC RNA-sequencing datasets from heroin-users and controls to identify transcripts predictive of heroin use.
Medications for Opioid Use Disorder in People Who Inject Substances: Reflection on the Potential Place of Morphine Sulfate as Substitution Treatment? Results of COSINUS Cohort Study.
Subst Use Misuse
December 2024
Centre d'étude des mouvements sociaux (Inserm U1276, /UMR CNRS 8044, /EHESS/Paris), Paris, France.
Background: Opioid Use Disorder (OUD) often provokes dramatic consequences in terms of increased morbi-mortality. Two medications have mainly been worldwide used for OUD (MOUD), buprenorphine and methadone. Recently, however, some reports have highlighted the use of Morphine Sulfate (MS) mainly obtained without a prescription but used as MOUD by opioid users and especially People Who Inject Substances (PWIS).
View Article and Find Full Text PDFPatterns and Characteristics of Amphetamine-type Stimulant Use in a North-eastern State of India: A Cross-sectional Study.
Indian J Psychol Med
April 2024
Indian Drug Users Forum, New Delhi, India.
Article Synopsis
- This study investigates the patterns of amphetamine-type stimulant (ATS) use and high-risk behaviors among adults in Manipur, India, revealing that the majority of users engage in daily use and dependence on substances.
- Most participants reported significant health issues related to ATS, including a tendency to inject drugs and risky sexual behavior, such as unprotected sex.
- The findings indicate a need for targeted strategies in India to address and reduce ATS use and its associated physical and psychological consequences.
DRAMES and DTA databases: Complementary tools to monitor drug-related deaths in France.
Therapie
October 2024
Addictovigilance Dept, Grenoble-Alpes University Hospital, 38000 Grenoble, France.
Introduction: The DRAMES (décès en relation avec l'abus de médicaments et de substances) registry is a French database of drug-related deaths (medications or illicit drugs) among drug users. The DTA (décès toxiques par antalgiques) registry is a French database of analgesic-related deaths among people without a history of drug abuse. Both registries are based on the collection of data on deaths for which forensic toxicology experts have performed analyses.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!