Background And Purpose: Large artery occlusion (LAO) in ischemic stroke requires recognition and triage to an endovascular stroke treatment center. Noninvasive LAO detection is needed to improve triage.
Methods: Prospective study to test whether noninvasive cerebral oximetry can detect anterior circulation LAO in acute stroke. Interhemispheric ΔBrSO in LAO was compared with controls.
Results: In LAO stroke, mean interhemispheric ΔBrSO was -8.3±5.8% (n=19), compared with 0.4±5.8% in small artery stroke (n=17), 0.4±6.0% in hemorrhagic stroke (n=14), and 0.2±7.5% in subjects without stroke (n=19) (<0.001). Endovascular stroke treatment reduced the ΔBrSO in most LAO subjects (16/19). Discrimination of LAO at a -3% ΔBrSO cut had 84% sensitivity and 70% specificity. Addition of the G-FAST clinical score (gaze-face-arm-speech- time) to the BrSO measure had 84% sensitivity and 90% specificity.
Conclusions: Noninvasive cerebral oximetry may help detect LAO in ischemic stroke, particularly when combined with a simple clinical scoring system.
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