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Isolation and purification of diterpenoids from the aerial parts of Isodon excisoides target-guided by UPLC-LTQ-Orbitrap-MS. | LitMetric

AI Article Synopsis

  • - The study focused on extracting and analyzing cytotoxic diterpenoids from the plant Isodon excisoides using advanced techniques like UPLC-LTQ-Orbitrap-MS.
  • - Four diterpenoids were identified: a novel compound designated 1α-acetoxy-7α, 14β, 20α-trihydroxy-ent-kaur-16-en-15-one and three known compounds: kamebakaurin, lasiokaurin, and enmenol-1-β-glucoside.
  • - Compounds 1 and 2 exhibited significant cytotoxic activity against various human cancer cell lines, with IC values between 1.06 and 3.60 μM, while compounds

Article Abstract

Cytotoxic diterpenoids were enriched and orientation prepared from the aerial parts of Isodon excisoides target-guided by UPLC-LTQ-Orbitrap-MS. Four diterpenoids were obtained, including a novel compound: 1α-acetoxy-7α, 14β, 20α-trihydroxy-ent-kaur-16-en-15-one (1); together with three known compounds kamebakaurin (2), lasiokaurin (3), enmenol-1-β-glucoside (4). Their structures were elucidated on the basis of spectroscopic methods in conjunction with published data for their analogues. All compounds were tested for their cytotoxic effects against five human cancer cell lines HCT-116, HepG2, A2780, NCI-H1650 and BGC-823, respectively. Compounds 1 and 2 showed obviously cytotoxic activity against the five cancer cell lines with IC ranging from 1.06 to 3.60 μM. Compounds 3 and 4 showed selective cytotoxic activity.

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Source
http://dx.doi.org/10.1080/14786419.2017.1419225DOI Listing

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