AI Article Synopsis
- The study evaluated the outcomes of bladder augmentation (BA) performed simultaneously with kidney transplantation (KT) at a single center.
- Compared to patients who only received KT, those who underwent BA-KT had similar early surgical complications but better early graft function, although they experienced higher rates of urinary issues like asymptomatic bacteriuria and urinary tract infections.
- Long-term results showed a significant decline in graft function for the BA-KT group by the fifth year, with graft loss attributed to recurrent UTIs and patient noncompliance with medication.
Article Abstract
Background: Guidelines for bladder augmentation (BA) in kidney transplantation (KT) recipients are not well-defined. In our center, simultaneous BA with KT (BA-KT) is performed. We assessed transplantation outcomes of this unique extensive procedure.
Methods: A case-control single center retrospective study. Transplantation outcomes were compared with those of KT recipients who did not need BA.
Results: Compared with 22 patients who underwent KT only, for 9 who underwent BA-KT, surgical complications and the need for revision in the early posttransplantation period were similar; early graft function was better: estimated glomerular filtration rate, 96.5 ± 17.1 versus 79.4 ± 16.6 mL/min at 0 to 6 months (P = 0.02); posttransplantation clean intermittent catheterization was more often needed: by 78% (7/9) versus 13% (3/22); and asymptomatic bacteriuria was more common: 100% versus 9% during the first 6 months (P < 0.001), 55% versus 9% (P = 0.02) and 66.6% versus 9% during the first and second years, respectively (P = 0.004). Urinary tract infection (UTI) incidence was also higher: 100% versus 23% during the first 6 months and 44% versus 9% during the second year posttransplantation. Graft function deteriorated significantly in the BA-KT group by the fifth posttransplantation year: estimated glomerular filtration rate was 47.7 ± 39.7 mL/min versus 69 ± 21.3 mL/min, with only 6 (66%) of 9 functioning grafts versus 100% in the KT only group. Causes of graft loss were noncompliance with drug therapy in 2 patients and recurrent UTIs in 2 patients.
Conclusions: Excellent short-term outcome for simultaneous BA-KT is threatened by graft loss due to a high prevalence of UTIs and patient noncompliance with the demanding complex posttransplantation therapy.
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| http://dx.doi.org/10.1097/TP.0000000000002050 | DOI Listing |
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