Background: The present study was conducted approximately 40 years ago, but its results have not been released. At the time of this study, the importance of the gut microbiota was not fully understood.
Methods: rodents, as one of the major reservoirs of bacterium in Iran, were compared in a disease endemic area (Akanlu, Hamadan, western Iran) and a non-endemic zone (Telo, Tehran, Iran) from 1977 to 1981.
Results: This study was able to transmit the resistance to to other rodents creatively by using and transferring gut microbiota.
Conclusion: The study indicated for the first time that the gut microbiota could affect the sensitivity to plague in in Telo.
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