Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Nicotinamide mononucleotide supplementation ameliorates testicular damage induced by ischemia-reperfusion through reshaping macrophage and neutrophil inflammatory properties.
Int Immunopharmacol
March 2025
Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Department of Developmental & Regenerative Medicine, College of Life Science and Technology, Jinan University, Guangzhou, China. Electronic address:
Background: Ischemia-reperfusion (I/R) injury is the main pathophysiology of testicular torsion-detorsion (T/D). However, there is no safe and effective treatment for testicular I/R injury.
Methods: The levels of NAD related genes were measured in the sham group, I/R + saline-treated group, and I/R + NMN-treated group by quantitative reverse transcription PCR (qRT-PCR).
EWSR1::CREM Fusion in a Pediatric Patient With Testicular Leydig Cell Tumor.
Genes Chromosomes Cancer
March 2025
Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Sex cord-stromal tumors are rare in pediatric patients. Leydig cell tumors are a rare subset of sex cord-stromal tumors characterized by unique molecular alterations, including TERT fusions and mutations of CTNNB1, FOXO4, TP53, NBN, MTOR, BAP1, MEN1, and CREBBP. We report a case of a testicular Leydig cell tumor with an EWSR1::CREM fusion, which to our knowledge has not been previously reported in this setting.
View Article and Find Full Text PDFCorrigendum to "Icariin inhibition of NLRP3 mediated Leydig cell pyroptosis and insulin resistance ameliorates spermatogenesis disorders in obese mice" [Int. Immunopharmacol. 151 (2025) 114280].
Int Immunopharmacol
March 2025
Reproductive Hospital of Guangxi Zhuang Autonomous Region, No. 3, Longyuan Road, Qingxiu District, Nanning City, Guangxi 530000, China. Electronic address:
Diagnostic challenges of androgen secreting tumor by sclerosing stromal tumor: A case report.
Int J Surg Case Rep
February 2025
Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, dr. Cipto Mangunkusumo General Hospital - Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Yasmin IVF clinic, dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Reproduction, Infertility, and Family Planning Cluster, Indonesia Reproductive Medicine Research and Training Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia.
Introduction: Androgen-secreting tumors are rare ovarian or adrenal neoplasms associated with virilization symptoms such as hirsutism, deepening of the voice, and menstrual irregularities. These tumors present a diagnostic challenge due to overlapping features with conditions like polycystic ovary syndrome (PCOS) and congenital adrenal hyperplasia (CAH). Accurate diagnosis requires a combination of biochemical assays, imaging, and histopathological examination.
View Article and Find Full Text PDFCharacterisation of Leydig cell dysfunction in previous illicit androgen users.
J Clin Endocrinol Metab
March 2025
Department of Nephrology and Endocrinology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Background And Objectives: A few studies have explored the impairment of pituitary gonadotroph and Leydig cell function in men who recently ceased illicit androgen use, as assessed by stimulation tests. However, the capacity of the pituitary-testis axis in previous users who discontinued androgen use years ago remains unclear. This study evaluated the pituitary-testis-axis capacity in previous illicit androgen users and nonusers.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!