AI Article Synopsis
- - Recent reports indicate the emergence of new DS-1-like G3 rotaviruses, specifically the G3P[8] strains, found in children with severe diarrhea in Japan during the 2015-2016 rotavirus surveillance.
- - Researchers sequenced and analyzed the full genomes of three identified strains, which exhibited a unique combination of genes from different genogroups, specifically G3-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2.
- - Phylogenetic analysis suggested that these strains are reassortants, having acquired genetic material from equine G3 rotaviruses while maintaining a genetic backbone from DS-1-like G1P[8]
Article Abstract
The emergence and rapid spread of novel DS-1-like intergenogroup reassortant rotaviruses having the equine-like G3 genotype (DS-1-like G3P[8] strains) have been recently reported from several countries. During rotavirus surveillance in Japan in 2015-2016, three DS-1-like G3P[8] strains were identified from children with severe diarrhea. In the present study, we sequenced and characterized the full genomes of these three strains. On full-genomic analysis, all three strains showed a unique genotype constellation including both genogroup 1 and 2 genes: G3-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. Phylogenetic analysis revealed that each of the 11 genes of the three strains was closely related to that of Japanese DS-1-like G1P[8] and/or Japanese equine-like G3P[4] human strains. Thus, the three study strains were suggested to be reassortants that acquired the G3-VP7 gene from equine G3 rotaviruses on the genetic background of DS-1-like G1P[8] strains. Our observations will provide important insights into the evolutionary dynamics of emerging DS-1-like G3P[8] strains.
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| http://dx.doi.org/10.1002/jmv.25016 | DOI Listing |
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Article Synopsis
- G3P rotaviruses have a unique genetic makeup and complex evolution, yet they have been under-researched, limiting understanding of rotavirus diversity.
- Recent studies identified two new G3P strains in Chinese diarrhea patients, showing a previously unreported genetic constellation in China, which closely relates to feline and bovine rotavirus strains.
- Phylogenetic analysis indicates that the G3P strains from Ningxia originated from reassortment among various rotaviruses, suggesting a complex evolutionary history with ties to both human and animal strains.
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